PPI Network Service

PPI Network Service 1

Protein-protein interaction (PPI) is a highly specific physical contact established between two or more protein molecules, which results from biochemical events generated by the interaction. These interactions include electrostatic forces, hydrogen bonding and hydrophobic effect. Many are physical contacts of molecular associations that occur in cells or living organisms in a specific biomolecular environment. Various studies have been carried out on PPI and from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, etc. All of this information can create large protein interaction networks similar to metabolic or genetic/epigenetic networks that can enhance existing knowledge of the biochemical cascade of diseases and molecular etiology, and can discover therapeutically meaningful proteins target.

Features

  • PPI network represent the physical relationships between proteins. They are central to practically every process that takes place in the cell.
  • Proteins are represented as nodes that are linked by undirected edges.

PPI Network Service 2

Classifications of Protein-protein interaction

  • Stable interactions are formed in protein complexes (e.g. ribosome, haemoglobin).
  • Transient interactions are brief interactions that modify or carry a protein, leading to further change (e.g. protein kinases, nuclear pore importins). They constitute the most dynamic part of the interactome.

Our PPI network service

Project name PPI network service
Samples requirements Our network analysis services in biology require you to provide specific requirements.
Detection cycle Decide according to your needs.
Service including We provide you with raw data and modeling results.
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Significance of our PPI network service

Protein-protein interaction (PPI) is essential for almost every process in a cell, so understanding PPI is essential for understanding cell physiology in normal and disease states. This is also important in drug development because drugs can affect PPI. egg

PPI knowledge can be used to:

  • Give a presumed role to uncharacterized proteins;
  • Add fine-grained details about the steps within the signal path; or Characterize the relationship between proteins (such as proteasomes) that form multimolecular complexes.

PPI Network Service 3

Applications for PPI network service

  • Assign putative roles to uncharacterised proteins;
  • Add fine-grained detail about the steps within a signalling pathway;
  • Characterise the relationships between proteins that form multi-molecular complexes such as the proteasome.

ComputaBio can provide data mining services to study the PPIs, such as:

PPI Network Service 4

  • Prediction of interacting sites of proteins.
  • Reliability Assessment of Protein-Protein Interactions.
  • Establishment of interaction networks for specific collections of proteins, and involved with pathological/physiological processing.

ComputaBio provides corresponding PPI network service. Our PPI network service have proven to be very useful for understanding the biochemical basis of physiological events at different stages of drug development (even in different fields such as materials science). ComputaBio team has been working in this field for more than ten years and has published his findings in top scientific journals. If you have a need for network analysis services, please feel free to contact us.

We provide a variety of modeling services, but not limited to:

* It should be noted that our service is only used for research, not for clinical use.

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