MEMBRANE PROTEINS

Membrane proteins account for about 20% to 30% of all proteins encoded in a typical genome. They play central roles in the transport of nutrients and metabolites, and in the signaling of regulatory networks. A major obstacle in studying membrane proteins is the difficulty in experimental determination of their three-dimensional structures. Computational studies of membrane proteins can complement experimental studies and have made significant strides.

• Computational studies of membrane proteins based on physical models with parameters derived from bioinformatics analysis.
• Computational identification of membrane proteins and prediction of their topology from the sequence.
• Discovery of sequence and spatial motifs, and implications of these discoveries.
• Detection of evolutionary signals for understanding the substitution pattern of residues and for sequence alignment.
• Calculation of ensemble properties such as melting temperature based on simplified state space model.
• Prediction of oligomerization state of membrane proteins.
• Identification of the interfaces for protein-protein interactions.
• Design of membrane proteins.

CD ComputaBio provides membrane proteins at crystallography grade for computational research applications.