Recombinant Human SMARCA2 Protein (aa 700-1216), His-tagged

Product Details

Catalog

CPB-B015

Product Name

Protein Name

Short isoform of probable global transcription activator SNF2L2

UniProt

P51531

Type

BROMODOMAINS PROTEINS

Description

High purity crystallization grade drug target recombinant proteins are ready to be shipped to customers for research purposes. The proteins have been purified to a high degree, characterized and crystallized.

Origin

Human

Source

Yeast

Gene Information

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Synonyms

BAF190B, BRM, SNF2A, SNF2L2

Tag

His

Storage

Store at -80°C.

Applications

Research Use

Grade

Crystallography grade protein

Size

0.5mg / 1mg

* For Research Use Only.

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