Protein Mass Spectrometry Characterisation Service
Protein Mass Spectrometry Characterisation Service
Inquiry
At CD ComputaBio, we pride ourselves on providing state-of-the-art Protein Mass Spectrometry Characterisation Services. Mass spectrometry (MS) is a pivotal tool in proteomics, allowing for the detailed analysis of protein structures and functions. Our cutting-edge technology and advanced computational algorithms enable us to deliver precise and comprehensive protein characterization, critical for various applications in biomedical research, pharmaceuticals, and biotechnology.
Backgroud
The characterization of proteins through mass spectrometry has revolutionized the field of proteomics. Proteins, the workhorses of cells, play crucial roles in virtually all biological processes. Understanding their structure, post-translational modifications, and interactions is essential for deciphering cellular mechanisms and developing therapeutic interventions. Traditional methods often fall short in resolution and sensitivity, but mass spectrometry bridges these gaps, offering unparalleled insights into protein composition and behavior.
Figure 1. Protein Mass Spectrometry Characterisation.(From Wikipedia)
Our Service
CD ComputaBio offers a suite of services tailored to meet diverse protein characterization needs. Our services include but are not limited to:
Services
Description
Protein Identification:
Utilizing tandem mass spectrometry (MS/MS) for the precise identification of proteins in complex mixtures.
Post-Translational Modification Analysis
Identifying and quantifying modifications such as phosphorylation, glycosylation, ubiquitination, and more.
Protein-Protein Interaction Studies
Mapping interaction networks to understand functional protein assemblies.
Bioinformatics Analysis
Comprehensive data analysis using in-house developed algorithms and software tools for interpreting mass spectrometry data.
Applications
Our protein mass spectrometry services are versatile and applicable across various sectors:
Drug Discovery and Development: Identifying drug targets and biomarkers, and understanding drug mechanisms of action.
Clinical Research: Biomarker discovery for disease diagnosis and prognosis, and monitoring therapeutic efficacy.
Biotechnology: Quality control of recombinant proteins, assessment of biotherapeutics, and enzyme engineering.
Our Algorithm
De Novo Sequencing
Assemble peptide sequences from mass spectrometric data without the need for a reference database.
Database Searching
Cross-reference spectral data with protein databases to pinpoint protein identities.
Quantitative Analysis
Apply statistical models to quantify protein expression across different samples.
Sample Requirements
To utilize our Protein MS Spectrum Characterization Service, clients are required to provide:
Details of the protein sample, including sequence.
Any additional experimental conditions or constraints
Results Delivery
At CD ComputaBio, we guarantee timely and accurate results through:
Data Reporting: Comprehensive reports detailing identified proteins, post-translational modifications, and quantitative data.
Visualization: High-quality graphical representations of spectra and quantification results.
Raw Data Access: Provision of raw mass spectrometry data for further in-depth analysis by the client.
Our Advantages
Advanced Technology
Utilization of the latest mass spectrometry instruments and techniques.
Expert Team
Our team comprises experienced scientists with deep expertise in proteomics and mass spectrometry.
Support and Consultation
Ongoing support and expert consultation to maximize the value of your data.
Protein mass spectrometry characterization is a cornerstone of modern proteomics, providing essential insights into protein functions, interactions, and modifications. At CD ComputaBio, we combine advanced technology, expert knowledge, and proprietary algorithms to deliver high-quality, reliable protein characterization services.
Frequently Asked Questions
What is Protein Mass Spectrometry?
Protein Mass Spectrometry is a powerful analytical technique used to analyze protein composition, structure, and function. It involves ionizing protein molecules and measuring their mass-to-charge ratios (m/z) to obtain detailed information about the protein’s characteristics. The results provide insights into molecular weight, sequence, modifications, and interactions, which are crucial for understanding biological processes and developing therapeutic strategies.
What types of proteins can you analyze?
Our Protein Mass Spectrometry Characterisation Service can analyze a wide variety of protein types, including but not limited to:
Native Proteins: Isolated from biological sources in their natural form.
Post-Translationally Modified Proteins: Such as phosphorylated, glycosylated, or ubiquitinated proteins which can provide insights into cellular signaling and regulation.
Membrane Proteins: Though often challenging to analyze due to their hydrophobic nature, we utilize specific methods to prepare and analyze these essential proteins.
Complex Protein Mixtures: In proteomics studies, we can analyze complex samples that contain multiple proteins to identify profiles and interactions.
What are the advantages of using your Protein Mass Spectrometry Characterisation Service?
Choosing our Protein Mass Spectrometry Characterisation Service offers several advantages:
Expertise: Our team consists of experienced professionals specializing in mass spectrometry and protein characterization.
State-of-the-Art Technology: We utilize cutting-edge mass spectrometers and preparation techniques to ensure high sensitivity and accuracy.
Customizable Services: We offer tailored analytical services based on specific research needs, whether it be qualitative, quantitative, or structural analysis.
What information can be derived from Protein Mass Spectrometry?
The analysis of proteins using mass spectrometry can yield a wealth of information, including:
Molecular Weight: Determining the mass of proteins or peptides provides insights into their identity and purity.
Amino Acid Sequence: By performing tandem MS (MS/MS), we can deduce the sequence of peptides and thus infer the protein sequence.
Protein Structure: Secondary structure elements and folding states can be characterized.
Protein-Protein Interactions: By using techniques like Cross-Linking Mass Spectrometry, we can infer interactions between proteins.
For research use only. Not intended for any clinical use.
Figure 1. Protein Mass Spectrometry Characterisation.(From Wikipedia)
