B cell maturation antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (tnfrsf17), is a protein encoded by tnfrsf17 gene in human body. Serum B-cell maturation antigen (sBCMA), a cleaved form of BCMA, is low in the serum of normal patients and usually elevated in patients with multiple myeloma (mm). The protein encoded by this gene is a member of TNF receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to tumor necrosis factor (ligand) superfamily member 13b (TNFSF13B/TALL-1/BAFF) and lead to NF kappaB and mapk8/JNK activation. The receptor also binds to various TRAF family members, so it can transduce signals of cell survival and proliferation. CD ComputaBio now offers professional BCMA targeting services to meet your research needs.
Our Services
- Virtual Screening Service
We provide a one-stop virtual screening (VS) service, which is active compound screening based on small molecule databases. Using the molecular docking operation between small molecule compounds and drug targets, virtual screening can quickly screen out druggable active compounds from tens of millions to millions of molecules, greatly reducing the number of experimentally screened compounds and shortening the research time. There are two main types of virtual screening methods: structure-based virtual screening (SBVS) and ligand-based virtual screening (LBVS).
- BCMA Inhibitor Design Service
Our inhibitor design services can be used for feasibility assessment and structure-activity relationship studies of new drug targets. Our computer-aided design service saves a lot of labor costs, the calculation cycle is short, the speed is fast, the funds required are far less than biological or chemical experiments, and the calculation accuracy is high. We provide the following four methods for you to choose from：
- Residue Interactions Prediction
- Ligand Binding Site Prediction
- Residue Interaction Network Service
RIN represents a three-dimensional protein structure as a set of nodes (residues) and their connections (edges). Topological parameters calculated from RIN are relevant to various aspects of protein structure and function. We can provide complex analysis of proteins and their complexes and predict different properties and functions of individual residues and whole proteins by using RIN analysis. The chemical and physical properties of bases and the energy of their interactions are analyzed by constructing RINs.
Our Capabilities
CD ComputaBio provides professional BCMA targeting services to meet customers' scientific needs. CD ComputaBio relies on world-class technical expertise, we provide customers with the highest quality one-stop BCMA targeting services, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more details and our scientists will tailor the most reasonable plan for your project.
Our Molecular Dynamics Results Analysis Service Targeting BCMA
Molecular dynamics (MD) is a computer simulation method used to analyze the physical motion of atoms and molecules. Having atoms and molecules interact with each other for a fixed amount of time gives a dynamic "evolution" view of the system. We provide a range of results analysis services, including but not limited to:
* For Research Use Only.
