Glycomics Analysis Service
Glycomics, the comprehensive study of glycans and their biological functions, plays a crucial role in understanding cellular communication, disease mechanisms, and therapeutic development. CD ComputaBio offers state-of-the-art glycomics analysis services, leveraging cutting-edge transcriptomic data and bioinformatics tools to decode glycan structures, interactions, and functional roles. By integrating multi-omics approaches, our service provides a comprehensive understanding of glycosylation patterns and their implications in health and disease.
Introduction to Glycomics Analysis
Glycomics, at its core, involves the collection, analysis, and exploitation of glycan-related biological data on a glycome-wide scale. The profound impact of glycosylation on lipids and proteins has elevated glycomics to a pivotal realm within the life sciences. Glycomics analysis proves invaluable for comparing distinct glyco-engineered host strains for therapeutic glycoprotein production or assessing various stages of cancer, offering potential insights into novel biomarkers.
Figure 1. Glycomics Analysis. (Ma T, et al., 2022)
Our Services
CD ComputaBio use advanced analytical methods such as mass spectrometry, liquid chromatography, microarray, fluorescence and NMR spectroscopy to identify putative targets. We offer a wild range of glycomics services, including:
- N-Glycan Linkage Analysis Service
- O-Glycan Profiling
- Lignin Content Analysis
- Glycan Sequencing
- Glycoproteomics Service
- N-Glycosylation Site Occupation
- Cellulose Content Analysis
- Structural Characterization of Glycans
By Workflow
Sample Preparation: The initial step, sources include cells, tissues, and body fluids. After collection, samples are processed to isolate glycans or glycoconjugates, with procedures like cell lysis, protein precipitation, or lipid extraction.
Glycan Extraction and Purification: Glycans are extracted from the sample matrix post-preparation. Methods vary by sample type and glycan nature, such as using glycosidases for N-linked glycans on glycoproteins. Subsequently, glycans are purified.
Glycomics Analysis: Purified glycans are analyzed with advanced methods. Mass spectrometry, is used for glycan identification and quantification. NMR spectroscopy further resolves glycan structures by detailing sugar residues and linkages.
Data Analysis and Interpretation: Complex analytical data is processed with specialized bioinformatics tools. Tasks involve peak identification, glycan quantification, and structure determination.
Our Advantages
High-Resolution Analysis
CD ComputaBio's advanced technologies enable high-resolution glycomics analysis. Mass spectrometry detects low-abundance glycans, while NMR precisely resolves complex glycan structures, crucial for identifying early-disease or process-related glycan changes.
Integration with Other Omics Data
The service integrates glycomics with transcriptomics and other omics data. This combination uncovers regulatory links between gene expression and glycosylation, offering a holistic view of cellular functions and disease mechanisms, and facilitating a systems-biology research approach.
Customized Service to Meet Specific Research Needs
Acknowledging diverse research requirements, CD ComputaBio provides customized glycomics analysis. Tailored to specific cells, tissues, diseases, or preferred methods, it delivers targeted results, enhancing the value of glycomics analysis for individual research projects.
CD ComputaBio understands that different research projects have unique needs and therefore offers customized glycomic analysis services. Whether the research focus is on a specific type of cell, tissue, or disease, our services can be tailored. This flexibility ensures that researchers can obtain the most relevant and useful results for their specific research questions, maximizing the value of glycomic profiling in their research. If you are interested in our services or have any questions, please feel free to contact us.
Reference:
- Ma T, McGregor M, Giron L, et al. Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV. Elife, 2022, 11: e78870.
* For Research Use Only.
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