In the field of molecular biology, myocyte enhancer factor 2 (Mef2) protein is a family of transcription factors, which is an important regulator of cell differentiation by controlling gene expression, and therefore plays a key role in embryonic development. In adult organisms, Mef2 protein mediates the stress response of certain tissues. Mef2 protein contains both MADS-box and Mef2 DNA binding domain. MEF2 is a transcription factor with four specific numbers, such as MEF2A, B, C, and D. Each MEF2 gene is located on a specific chromosome

Our Services

• Help you find genes related to MEF2 regulation.
• Analysis of gene network related to MEF2 regulation.
• Related gene co-expression network analysis.
• Related microRNA and target gene network diagram service.
• Related transcription factor analysis and network construction service.
• Provide MEF2 agonist design services to meet your scientific research needs.
• Provide structural optimization and energy minimization services for the selected advantageous ligands.
• Provide molecular dynamics simulation and molecular docking services between agonists and MEF2.
• Choose the appropriate molecular dynamics simulation conditions for you.
• Provide related result analysis service.

Provided by Clients

Please inform us of the details about your MEF2 targeting research project after signing a non-disclosure agreement, which can be specific to the force field of molecular dynamics simulation, and the result analysis requirements.

Deliverables

•  The original structure of designed small molecule agonist
•  Gene network analysis results
•  Gene co-expression network analysis results
•  MicroRNA and target gene network diagram results
•  Transcription factor analysis results
•  Network construction service results
•  The initial structure of the simulation system
•  Raw data of molecular dynamics results
•  Other calculation and analysis results

Our advantages

• CD ComputaBio team members are all experts in computational biology and have rich experience in target calculations.
• We assist clients in completing various research projects. Through experiments and calculations, we provide customers with high-quality target analysis services, help customers publish articles, and recommend scientific research progress.
• Based on high-quality data analysis, the analysis content and methods verified by the pre-research are indeed mature and feasible.

If you want to know more about MEF2 targeting services provided by CD ComputaBio, please contact us at any time.

Reference:

1. Barker S.J., Raju R.M., Milman N.E.P., et al. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration. Science Translational Medicine, 2021.