ⓘ Introduction
Hantaviruses are zoonotic pathogens that can cause severe diseases in humans, including hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The lack of approved antivirals or licensed vaccines highlights the urgent need for innovative therapeutics and diagnostics.
The Gn and Gc envelope glycoproteins mediate host cell receptor binding and membrane fusion, making them principal targets for neutralizing antibodies. The nucleoprotein (NP) is highly conserved and critical for viral replication, serving as a valuable target for diagnostic and therapeutic strategies.
