Antibody Modeling Services


Antibody Modeling Services

Antibodies are proteins that play a key role in recognizing various antigens in our immune system. Antibodies are increasingly used as diagnostic tools and therapeutic drugs. An important part of the antibody engineering process is the availability of high-quality three-dimensional structures. Experimental determination of antibody structure is laborious and not always possible. Computational modeling is an efficient and inexpensive way to generate antibody structural models.

Overall solution

The variable domains (Fv) of the heavy and light chains have special significance in structural modeling because they usually confer most or all of the specificity of antibodies against their antigen targets. Antibody Fv region modeling involves prediction of the framework (FR) and variable loop (CDR) regions.

  • Our protocol first searches for a framework antibody (FR) from a templated database, which is derived from a crystal structure that is publicly available in a protein database (PDB).
  • Process of antibody modeling service.

  • Thereafter, the template of the CDR region is selected from the canonical loop conformations aggregated in the database based on homology. Then, with the refinement of the H3 loop, a structural model of the Fv region is established. The entire antibody including the constant region (Fc) can also be modeled.

Our services

Project name Antibody modeling services
Samples requirement Our antibody modeling services requires you to provide specific requirements.
Timeline Decide according to your needs.
Deliverables We provide you with raw data and calculation result analysis service.
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CD ComputaBio provides corresponding antibody modeling services. Our antibody modeling services has proven to be very useful for understanding the biochemical basis of physiological events at different stages of drug development (even in different fields such as materials science). Our team of experts can provide accurate modeling of the system you choose, so you do not have to worry about technical issues. We can also analyze these results for you. CD ComputaBio team has been working in this field for more than ten years and has published his findings in top scientific journals. If you have a need for protein structure modeling services, please feel free to contact us.

We provide a variety of modeling services but not limited to:

* For Research Use Only.
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