The interaction between proteins is essential. It is the basis of all metabolic activities of the cell. In order to better understand the biological activity of cells, the function of protein monomers and complexes must be well understood, which will involve the study of protein interactions. Recognizing and studying protein-protein docking is an important research content in life sciences. Drug molecules used to treat diseases usually regulate or block protein-protein interactions, so protein-protein interaction sites also represent an important class of drug targets. Computational methods can well supplement the experimental determination of the structure of complexes when studying protein docking.
|Bound docking||The protein structure used in the docking comes from the complex they form.|
|Unbound docking||The protein structure used in unbound docking comes from the monomer structure when they are not bound to other proteins in most cases. One difficulty of unbound docking is the change of protein conformation.|
Figure 1. Protein-protein docking process.
|Project Name||Protein-Protein Docking Service|
|Samples requirement||Our protein-protein docking service requires you to provide specific docking requirements.
We can offer you with the following services but not limit to:
|Timeline||Decide according to your needs.|
|Deliverables||We provide you with raw data and calculation result analysis service.|
CD ComputaBio' protein-protein docking is the main method used in structure-based drug design. This technology is to place the ligand molecule in the position of the active site of the receptor molecule, and then in real time according to the principles of geometric complementation, energy complementation and chemical environment complementarity. Evaluate how well the ligand interacts with the receptor, and find the best binding mode between the two molecules. In drug design, the molecular docking method is mainly used to search for small molecules with good affinity with the receptor biomacromolecule from the small molecule database, and conduct pharmacological tests to discover new lead compounds. If you have service needs for molecular docking, please feel free to contact us.
A: The algorithm of protein-protein docking involves predicting the binding mode and energy of two or more protein molecules based on their 3D structures. The process typically involves several steps, including rigid-body docking, refinement, scoring, and analysis.
A: protein-protein docking techonoly has the following applications:
A: ZDock, ClusProh and Rosetta can be used for protein-protein docking. ZDock is a fast and efficient docking program that uses shape complementarity to generate initial models. based docking program that uses scoring functions based on energy minimization and Monte Carlo simulations.
A: Protein-protein docking service has the following advantages:
A: Protein-protein docking services typically offer several programs, including interaction details, energy analysis, qing'jian hydrogen bonding analysis, etc. Some protein-protein docking services may also offer additional features such as clustering analysis, energy minimization, and cross-docking experiments.