DKK1 is a protein encoded by the DKK1 gene in humans. The protein encoded by this gene is a member of the dickkopf family. It is a secreted protein with two cysteine-rich regions involved in embryonic development by inhibiting the Wnt signaling pathway. Dickkopf WNT signaling inhibitor 1 (Dkk1) is a protein-coding gene that acts on the anterior visceral endoderm. The dickkopf protein, encoded by DKK1, is an antagonist of the Wnt/β-catenin signaling pathway, and it acts by dissociating the LRP6 coreceptor so that it cannot help activate the WNT signaling pathway. DKK1 has also been shown to antagonize the Wnt/β-catenin pathway by reducing β-catenin and increasing OCT4 expression. This inhibition plays a critical role in the development of the heart, head, and forelimbs during embryonic anterior morphogenesis. Now, CD ComputaBio offers professional DKK1 targeting services to meet your research needs.
Our Services
- Binding Mode Prediction
Binding mode prediction study the interaction of active small molecule inhibitors with DKK1 targets and understand their mechanism of action. For binding mode prediction, we need to examine the reproducibility of the combined conformations of the docking software (methods), i.e. re-dock or self-dock. Systems suitable for binding pattern analysis include, but are not limited to:
- Protein-protein interaction system
- Protein-Small Molecule Interaction System
- Peptide Interaction System
- DNA-Small Molecule Interaction System
- RNA-Small Molecule Interaction System
- Computer Aided Drug Design
The computer-aided drug design services we provide are based on computational chemistry, a method to design and optimize lead compounds through computer simulation, prediction and budgeting of the relationship between small molecule compounds (inhibitors) and DKK1. Service details generally include active site analysis, database searches, and molecular docking.
- QSAR Service
Mathematical models are used to describe the relationship between the structure of a molecule and a certain biological activity of the molecule. The basic assumption is that the molecular structure of a compound contains information that determines its physical, chemical and biological properties, which in turn determine the biological activity of the compound. In turn, there should be some correlation between the data on the molecular structure properties of a compound and its biological activity.
Our Capabilities
Our DKK1 targeting service is based on computational biology and computational chemistry, combined with quantum chemistry, protein crystallography and protein dynamics research, to provide you with professional target computing services. It is our responsibility to meet your targeting service needs.
Our ADMET Prediction Strategies Targeting DKK1
We provide you with ADMET prediction services using computer-aided methods, our experts use project data or published data to predict ADMET properties of new compounds. We can also estimate these properties using ADMET QSAR models built by software vendors. A variety of computer models and massive pharmacology databases were used to accurately predict these properties, using project data or published data to construct QSAR and other models and predict the ADMET properties of new compounds, thus helping researchers eliminate molecules with poor ADMET properties and significantly reducing R&D costs. The main functions of ADMET services are as follows:
* For Research Use Only.
