The mammalian target of rapamycin (mTOR), also known as the mechanism target of rapamycin, is a kinase that encodes the MTOR gene in humans. mTOR is a protein kinase related to phosphatidylinositol 3-kinase). A member of the family. mTOR acts as a serine/threonine protein kinase, regulating cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy and transcription. mTOR also has the function of tyrosine protein kinase to promote insulin receptor Body and insulin-like growth factor 1 receptor activation.
Age-related cognitive impairment is a major destructive event that can even affect healthy people. Alzheimer's disease (AD) is the most common dementia in the elderly community. Recent studies have shown that mammalian target of rapamycin (mTOR) is a key target for AD cerebrovascular disorders. mTOR can cause cerebrovascular dysfunction and subsequent cerebral blood flow defects and cognitive impairment. In addition, mTOR can cause the breakdown of the blood-brain barrier (BBB) in the AD model. Inhibiting mTOR overactivity can protect the integrity of the BBB in AD. In addition, mTOR causes cognitive deficits and cerebrovascular dysfunction. Therefore, mTOR is a potential Alzheimer's disease (AD) target.
Our Services
- Design a series of small molecule inhibitors for the target mTOR. For the above inhibitors, we will optimize them and screen compounds using computer and high-throughput methods.
- Design peptide inhibitors for you against the target mTOR, and optimize the screening of inhibitors
- Using the molecular docking operation between small molecule inhibitors and drug targets, we provide virtual screening services, which can quickly screen out active compounds with drug-making capabilities. In addition, we also provide virtual screening between peptide inhibitors and drug targets.
- Provide molecular dynamics simulation services to study the details of the interaction between inhibitors and mTOR, and to further screen compounds with good binding affinity.
- Provide binding affinity analysis, energy analysis, hydrogen bond analysis and binding mode analysis services. Use statistical techniques to process data and analyze results.
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Help you find genes related to mTOR regulation, calculate mTOR regulation-related gene network analysis.
- Provide related transcription factor analysis and network construction services.
Provided by Clients
Please inform us of the details about your mTOR targeting research project after signing a non-disclosure agreement, which can be specific to the force field of molecular dynamics simulation, and the result analysis requirements.
Deliverables
- Design of the original structure of small molecule agonist
- Design of the original structure of peptide agonist
- Molecular docking score
- Virtual screening results
- The initial structure of the simulation system
- Raw data of molecular dynamics results
- Binding affinity analysis results
- Binding free energy analysis results
- Hydrogen bond analysis results
- Binding mode analysis results.
Our advantages
- CD ComputaBio has an advanced computational biology platform and an experienced scientific research team. Our advanced computational biology platform can provide highly reliable and reproducible results and high-quality one-stop service.
- We can generally complete the calculation service within a week. We can provide further after-sales service according to customer requirements.
- CD ComputaBio collaborates with scientists from many pharmaceutical and biotechnology companies. We have a wealth of knowledge and experience to provide quality assurance services.
If you want to know more about mTOR targeting services provided by CD ComputaBio, please contact us at any time.
Reference:
- Uddin M S, Rahman M A, Kabir M T, et al. Multifarious Roles of mTOR Signaling in Cognitive Aging and Cerebrovascular Dysfunction of Alzheimer's Disease. International Union of Biochemistry and Molecular Biology Life, 2020.
* For Research Use Only.
