CD ComputaBio can reengineer antibodies and antibody fragments into almost any format. The antibody variable region genes (VH and VL) from a given antibody can be reformatted to encode different constant regions, including Fab. In addition to changing the Fc portion of antibodies, the variable regions of immunoglobulins can also be reformatted into various fragments, such as Fab, F(ab)' 2, scFv, VHH and small antibodies, or can be combined with a bispecific secondary antibody. Smaller antibody formats can be used to improve tumor/tissue permeability and are relatively easy to express in non-mammalian systems.
In order to obtain ideal antibody fragments with good stability, serious recombination procedures are required before antibody production. Therefore, we provide the following computer-aided technologies for antibody design and reformatting.
By using these computer techniques, we can identify the main residues that affect certain characteristics of the target antibody. Afterwards, appropriate mutations can be made on these residues to change the properties of the antibody. In this way, the target antibody molecule can maintain relatively stable physical and chemical properties after reformatting, and maintain the original affinity and function. In addition, the external environment of the modified molecular model can be established, and it can be evaluated by RMSD, RMSF, and the potential energy inside the molecule.
|Project name||Antibody reformatting service|
CD ComputaBio offers the following antibody reformatting service to meet the specific needs of different customers:
|Timeline||Decide according to your needs.|
|Deliverable||We provide you with raw data and analysis service.|
CD ComputaBio's services are tailor-made for each project to ensure that goals are met or exceeded. An experienced project team will be assigned to each study, focusing on completing the progress of the project in the shortest possible time. Our customers widely regard us as a professional and attentive partner that provides quality results. Antibody reformatting service is an important service for understanding the life function of protein. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us.