Predicting the three-dimensional structure of an antibody is very important for antibody engineering including optimizing antibody affinity, specificity and stability. The most important part of antibody structure prediction is to predict the structure of antibody variable fragments (Fv), because the constant regions of antibodies are actually similar in all antibodies of the same isotype. Fv consists of two chains, a heavy chain variable domain (VL) and a light chain variable domain (VH). Each chain contains three hypervariable complementarity determining regions (CDR) that determine the interaction with the antigen. Because the framework regions of VL and VH domains are extremely conservative, the research of Fv structure prediction mainly focuses on the prediction of 6 CDR loops. Currently, CD ComputaBio can provide many methods for predicting antibody structure. We use sequence homology with natural antibody structure to select the backbone for modeling. If you have any needs in this regard, you can contact us at any time.
|Project name||Antibody structure prediction|
|Our services||CD ComputaBio offers antibody structure prediction service to meet the specific needs of different customers.|
|Timeline||Decide according to your needs.|
|Deliverable||We provide you with raw data and prediction results.|
CD ComputaBio provides professional antibody structure prediction service to meet the specific needs of regular customers on time and according to budget. CD ComputaBio relies on world-class technical expertise, we provide customers with the best quality one-stop antibody structure prediction service, including the development of scientific procedures according to different solution needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project. If you want to know more service prices or technical details, please feel free to contact us.