Affinity maturation is an important strategy in antibody optimization to generate safe and efficacious second-generation therapeutics. Therapeutic antibodies were obtained by immunizing mice or transgenic animals expressing human immunoglobulin genes with the desired antigen. Antigen-stimulated immune cells from these animals were transformed into hybridomas and subsequently screened to identify monoclonal antibodies with low nanomolar affinities for their target antigen. The development of efficacious antibodies with high specificity and affinity by in vitro affinity maturation is significant, as the possibility of smaller or infrequent dosing as well as the subsequent reduction in cost to the patient ensures a high success rate in the clinic.
|Project name||Antibody affinity maturation service|
|Our services||CD ComputaBio offers antibody affinity maturation service to meet the specific needs of different customers.|
|Timeline||Decide according to your needs.|
|Deliverable||We provide you with raw data and analysis service.|
CD ComputaBio' antibody affinity maturation service can significantly reduce the cost and labor of the subsequent experiments. Antibody affinity maturation service is a personalized and customized innovative scientific research service. Based on a better understanding of the nature of affinity maturation and the ability to selectively transform antibody sequence specificity, computer-assisted affinity maturation can be obtained through advanced antibody engineering techniques. Computational design mainly relies on accurate energy evaluation and thorough conformation search. Each project needs to be evaluated before the corresponding analysis plan and price can be determined. If you want to know more about service prices or technical details, please feel free to contact us.