Affinity maturation is an important strategy in antibody optimization to generate safe and efficacious second-generation therapeutics. Therapeutic antibodies were obtained by immunizing mice or transgenic animals expressing human immunoglobulin genes with the desired antigen. Antigen-stimulated immune cells from these animals were transformed into hybridomas and subsequently screened to identify monoclonal antibodies with low nanomolar affinities for their target antigen. The development of efficacious antibodies with high specificity and affinity by in vitro affinity maturation is significant, as the possibility of smaller or infrequent dosing as well as the subsequent reduction in cost to the patient ensures a high success rate in the clinic.

Overall solutions

• CD ComputaBio has established a comprehensive computer chip antibody design platform. Based on our platform can provide you with high-quality computer-assisted affinity mature services, we will do our best to promote the success of your project.
• CD ComputaBio uses thorough optimization techniques to perform a detailed ranking of the best solutions in the discretized search space.
• Based on our comprehensive antibody platform, new antibodies with desired therapeutic properties can be designed and engineered. We customize services according to customers' specific requirements. We also provide other epitope-specific antibody design services.

Why choose us?

• CD ComputaBio has a wealth of knowledge and experience. We cooperate with many people from all over the world, and the quality of our antibody affinity maturation service is guaranteed.
• Our research supervisor and project manager will communicate with you on project details at any time through open communication channels. We will complete your project on time and meet your requirements.
• CD ComputaBio has established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Our services

CD ComputaBio' antibody affinity maturation service can significantly reduce the cost and labor of the subsequent experiments. Antibody affinity maturation service is a personalized and customized innovative scientific research service. Based on a better understanding of the nature of affinity maturation and the ability to selectively transform antibody sequence specificity, computer-assisted affinity maturation can be obtained through advanced antibody engineering techniques. Computational design mainly relies on accurate energy evaluation and thorough conformation search. Each project needs to be evaluated before the corresponding analysis plan and price can be determined. If you want to know more about service prices or technical details, please feel free to contact us.

Related Services

• Antibody Humanization Service
• Antibody Drug Modifications Service