The interleukin 17 family (IL17 family) is a family of pro-inflammatory cystatin junction cytokines. They are produced by a group of T helper cells called T helper 17 cells in response to stimulation by IL-23. The biologically active IL-17 interacts with the type I cell surface receptor IL-17R. In turn, there are at least three variants of IL-17R, called IL17RA, IL17RB, and IL17RC. Upon binding to the receptor, IL-17 activates several signaling cascades, which in turn lead to chemokine induction. As chemoattractants, these chemokines recruit immune cells (e.g. monocytes and neutrophils) to sites of inflammation. CD ComputaBio now offers professional IL-17 targeting services to meet your research needs.
Our Services
- Fusion Protein Modeling Service
We offer professional fusion protein modeling services. Our structural modeling program requires either the selection of two protein components to be fused whose structures are known or computational modeling using an appropriately selected template. Then, an initial fusion model is created using the linkage between the two fusion partners and a union or domain insertion strategy. Afterwards, the final model is generated by calculating the conformation of the bridging fusion partner regions so that the protein structural domains move, rotate and interact to achieve a stable conformation.
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- Pathway and Network Analysis
CD ComputaBio will construct a signaling pathway regulatory network based on the mutual regulatory relationship between the pathways in which all differential genes are simultaneously involved, and study the signal transduction and regulation processes between various signaling pathways from a systematic perspective. We can discover core pathways and regulatory mechanisms in important signaling pathways that are affected by experiments.
- QSAR Service
Mathematical models are used to describe the relationship between the structure of a molecule and a certain biological activity of the molecule. The basic assumption is that the molecular structure of a compound contains information that determines its physical and biological properties, which in turn determine the biological activity of the compound. In turn, there should be some correlation between the data on the molecular structure properties of a compound and its biological activity.
Our Capabilities
CD ComputaBio has advanced computing platforms and independent target research groups to provide you with a variety of professional target analysis services. Our scientific research team is large in scale, with multi-disciplinary leading talents in drug research and development, immunology, physiology, biochemistry, etc., forming a technical team mainly with doctoral and master's degrees. CD ComputaBio can provide you with a cost-effective one-stop solution.
Our Molecular Simulation Strategies Targeting IL-17
- All-atom Molecular Dynamics Simulations
The steps of our molecular dynamic simulation service are as follows：First, a model system is chosen to repair the missing fragments and determine the protonation state. Then, the energy of the system is minimized and equilibrium is reached by solving the Newtonian equations of motion until the properties of the system no longer change with time. After equilibrium, a production run is performed for an appropriate time period to output the trajectory, which is then analyzed to obtain the features of interest.
- Coarse-grained Dynamics Simulations
For complex systems that are difficult to achieve with conventional all-atom simulations, we reduce the degrees of freedom of the simulated system by simplifying the details of the all-atom simulations, i.e., using coarse-grained dynamics simulations for system analysis.
* For Research Use Only.
