The melanoma antigen preferentially expressed in tumors is a protein that is encoded in humans by the PRAME gene. Five variable splice transcript variants of this gene encoding the same protein have been observed. The gene encodes an antigen that is predominantly expressed in human melanoma and recognized by lysogenic T lymphocytes. It is not expressed in normal tissues, except for the testis. This expression pattern is similar to that of other CT antigens such as MAGE, BAGE and GAGE. The overexpression of PRAME in tumor tissues and its relatively low levels in normal somatic tissues make it an attractive target for cancer therapy. CD ComputaBio now offers professional PRAME targeting services to meet your research needs.

Our Services

• Multi-Target Drug Design Services

Multi-target drugs can effectively modulate complex systems throughout the cell. Multi-target drugs can improve efficacy and safety, act on multiple disease-related targets, generate multiple pharmacological activities, obtain desirable diverse biomodulatory functions, and reduce side effects. Our multi-target drug solution steps include first detecting cracks or voids on the protein surface and coding the geometric and physicochemical properties of the voids. Comparisons are then made to find a set of targets with similar cavity properties. Ultimately, a multi-target ligand can be designed based on a set of targets with similar cavity properties.

• Biological Data Analysis

CD ComputaBio now offers comprehensive data analysis services to discover new knowledge from all types of biological data. We have created an efficient data analysis pipeline with a combination of mathematics and programming to perform the required analysis for a client's specific technical or biological research problem.

• Pharmacophore Model Construction

The construction of the pharmacophore model not only utilizes the molecular topological similarity but also the functional similarity of the groups, so that the concept of bioisosterism is used to make the model more reliable. Our pharmacophore modeling services can assist in target feasibility assessment and structure-activity relationship studies.

Our Capabilities

CD ComputaBio provides professional PRAME targeting services to meet customers' scientific needs. CD ComputaBio relies on world-class technical expertise, we provide customers with the highest quality one-stop PRAME targeting services, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more details and our scientists will tailor the most reasonable plan for your project.

Our Computational Peptide Strategies Targeting AChE

With the maturation of biotechnology and peptide synthesis, more and more peptide drugs are being developed and applied in the clinic. Due to the wide range of indications, high safety and remarkable efficacy, it is important to study the stability and binding affinity of peptide drugs at the computational level. In conjunction with our drug design platform, we offer peptide inhibitor design and construction services. It is important to study the stability and binding affinity of peptide drugs at the computational level, in addition to peptide drug design, we also offer the following services according to your needs: