CD ComputaBio now offers professional TLR5 targeting services using computational approaches to meet your research needs.
Toll-like receptor 5, also known as TLR5, is a protein encoded by the TLR5 gene in humans. It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellins from invading mobile bacteria. It has been shown to be associated with the onset of many diseases, including inflammatory bowel disease. Recent studies also suggest that malfunction of TLR5 may be involved in rheumatoid arthritis, osteoclastogenesis and bone loss. The TLR family plays an important role in pathogen recognition and innate immune activation. TLRs are highly conserved and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate the production of cytokines necessary for effective immunity. Abnormal TLR5 function is associated with the pathogenesis of gastric, cervical, endometrial and ovarian cancers.
Our Services
- TLR5 Regulator Design Service
CD ComputaBio designs small molecule compounds or peptide modulators for you to help you regulate the expression of TLR5 levels in vivo. Our design method mainly employs molecular docking and virtual screening. Virtual Screening (VS) is a small molecule database-based screening of active compounds. Using the molecular docking operation between small molecule compounds and drug targets, virtual screening can quickly screen out druggable active compounds from tens of millions to millions of molecules, greatly reducing the number of experimentally screened compounds.
- Umbrella Sampling Simulation Service
CD ComputaBio can provide you with umbrella sampling simulation technology. Umbrella sampling is a very popular technique for calculating mean force (PMF) to study protein binding-unbinding processes. Later, the binding free energy can also be extracted from the obtained PMF.
- Computational Peptide Services
More and more peptide drugs are developed and used in clinical practice. Due to the wide range of indications, high safety and remarkable efficacy, it is very important to study the stability and binding affinity of peptide drugs at the computational level. We provide a range of computational peptide services to meet your research needs, you can choose according to your needs.
Our Capabilities
CD ComputaBio provides specialized TLR5 target services. We will complete your project on time and efficiently. We have professional after-sales service: to provide customers with efficient and feasible solutions. We work with scientists from many pharmaceutical and biotech companies. We have extensive knowledge and experience to provide quality assurance services.
Our Network Analysis Service Targeting TLR5
We provide a professional network analysis service where different types of information can be represented in the form of networks to model cells. The meaning of nodes and edges used in network representation depends on the type of data used to construct the network. Different types of data also produce different general network characteristics in terms of connectivity, complexity, and structure, where edges and nodes may convey multiple layers of information. We offer a variety of network analysis services below for you to choose from.
* For Research Use Only.
