Vascular endothelial growth factor receptor 1 is a protein encoded by the FLT1 gene in humans. The oncogene FLT belongs to the src gene family and is associated with the oncogene ROS. Like other members of this family, it displays tyrosine protein kinase activity important for the control of cell proliferation and differentiation. It was also recently found that chemical and genetic ablation of VEGFR1 enhanced the conversion of white adipose tissue to brown adipose tissue and increased brown adipose angiogenesis in mice. Functional genetic variation in FLT1 has been found to affect survival in non-small cell lung cancer. CD ComputaBio now offers professional VEGFR-1 targeting services to meet your research needs.

Our Services

• Molecular Dynamics Simulation Service

Provide professional molecular dynamics simulation services. Molecular dynamics can be used for NPT, NVE, NVT and other ensemble calculations. It is a thermodynamic calculation method based on Newtonian mechanics determinism. The first step in a molecular dynamic simulation is to determine the initial configuration. The lower energy initial configuration is the basis for molecular simulations. Molecules identified in the previous step form an equilibrium phase whose configuration, temperature, and other parameters are monitored as the equilibrium phase is constructed. After entering the production phase, the molecules and atoms in the system begin to move at their initial speed. Using various states of the sampled system to calculate the potential energy of the system at that time, and then calculate the configuration integral.



• Target Prediction Service

Traditional methods include methods based on orientation docking and methods based on molecular fingerprints to calculate similarity. The reverse docking technique relies on the crystal structure of the protein. However, due to the inaccuracy of the scoring function, the current prediction accuracy is low. Similarity methods based on molecular fingerprints are widely used due to their high computational speed.

• Pathway and Network Analysis

Provide one-stop access and network analysis services. We will build a signaling pathway regulatory network based on the mutual regulatory relationship between the pathways in which all differential genes are involved at the same time, and study the signal transduction and regulation processes between various signaling pathways from a systematic perspective. We can discover the core pathways and regulatory mechanisms among the important signaling pathways affected by the experiments.

Our Capabilities

CD ComputaBio has successfully supported multiple target service programs. With deep scientific literacy and years of industry experience, our team brings increasingly deeper expertise and rich experience to our clients. We will complete your project on time and efficiently. We have professional after-sales service: to provide customers with efficient, fast and practical solutions. Relying on world-class technical expertise, we provide our customers with the highest quality one-stop target analysis services, including the development of experimental procedures for different experimental needs. Please feel free to contact us for more details and our scientists will tailor the most reasonable plan for your project.

Our Molecular Dynamics Results Analysis Service Targeting VEGFR-1

Molecular dynamics (MD) is a computer simulation method used to analyze the physical motion of atoms and molecules. Having atoms and molecules interact with each other for a fixed amount of time gives a dynamic "evolution" view of the system. We provide a range of results analysis services, including but not limited to:

• Hydrophobic Interaction Analysis Service
• Binding Mode Analysis Services
• Cluster Analysis Service
• RMSD Analysis Service
• PCA Analysis Service

Project Sample

Our computational biology team has extensive experience in the research of VEGFR-1 targets. The following is a small snapshot of our research process for reference only. For details, please feel free to consult our professional team.

Reference

Seki T, Hosaka K, Fischer C, et al. Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning. The Journal of Experimental Medicine. 2018, 215 (2): 611–626.