Amyloid beta precursor protein (APP) is a complete membrane protein expressed in many tissues and concentrated in neuronal synapses. It functions as a cell surface receptor and considered to be a modulator of synapse formation, neuroplasticity, antibacterial activity, and iron output. It is encoded by the gene APP and regulated by substrate presentation. APP is best known for its precursor molecule proteolysis to produce amyloid β (Aβ), which is a polypeptide containing 37 to 49 amino acid residues, and its amyloid fibrous form is the main component of amyloid plaques in patients with Alzheimer’s.
According to the "amyloid hypothesis", missense mutations in the APP gene promote the production of Aβ by facilitating the proteolytic processing of APP by β-or γ -secretase. In addition, the APP mutation within the A β sequence enhanced the self-aggregation of Aβ to amyloid fibrils. The cloning of presenilin (PS) protein and the mutations in PS1 and PS2 that cause AD also promote the processing of APP to form amyloid Aβ. During AD, the formation of Aβ is enhanced, which accelerates the process of neuron loss, so it can be assumed that the components of the apoptosis mechanism directly or indirectly contribute to the complex proteolytic process.
Our Services
- Provide professional ligand binding site prediction services: Many proteins require ligand binding to function properly. CD ComputaBio provides various bioinformatics tools to predict the binding sites of the ligand.
- Provide a one-stop fold recognition service, CD ComputaBio provides professional knowledge to help identify the correct structural fold in the known template protein structure of the target protein by combining sequence diagram alignment with multiple structural information.
- Provide target prediction services, we use specific calculation methods to predict the potential targets or pharmacological effects of compounds. Traditional methods include methods based on direction docking and calculation of similarity based on molecular fingerprints.
- Provide bioinformatics services, including gene function annotation and function enrichment analysis service, bioinformatic analysis-data preprocess and normalization service and bioinformatics data management service.
Provided by Clients
Please inform us of the details about your APP targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- Binding site prediction results and related residue analysis
- Raw data of folding recognition results
- Target prediction results
- Gene function annotation and function enrichment analysis results
- Bioinformatic analysis-data preprocess and normalization analysis results
- Bioinformatics data management service analysis results
- Other calculation and analysis results
Our advantages
- Equipped with skilled calculation operators, under the premise of ensuring quality, the project can be completed in a short time, and the calculation results are accurate and credible.
- Strict quality control system ensures high-precision computing services.
- Complete the result analysis, provide a detailed experimental process reports and deliver the product.
- CD ComputaBio can provide a true one-stop service experience, saving customers valuable time.
If you want to know more about APP targeting services provided by CD ComputaBio, please contact us at any time.
References
- Xuan, Cheng, Zhang, et al. Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics. BioMed research international, 2015.
* For Research Use Only.
