JNK is a protein kinase that can phosphorylate Ser63 and Ser73 at the amino terminal of c-Jun (a transcription regulator, a member of the leucine zipper family). It is a family of mitogen-activated protein kinase superfamily, including JNK1, JNK2, and JNK3. When Thr and Tyr in the activation motif Thr-Pro-Tyr are phosphorylated by JNKK1 and JNKK2, the activating enzyme can be activated. Phosphorylation of c-Jun and other proteins, thereby affecting the occurrence of cell apoptosis, inflammation and tumors.
JNK-mediated caspase-independent cell death plays an important role in tissue homeostasis during development. JNK signaling is a family of multifunctional signaling molecules that can be activated in response to a series of stress conditions and are effective inducers of cell death. More and more evidence collected in the AD model supports the involvement of JNK signaling in AD. It is reported that JNK can be activated by Aβ and induce the production of hyperphosphorylated Tau. In addition, inhibiting JNK with peptides can prevent cell loss in the AD model. Therefore, it is not only necessary to pay attention to the role of JNK in the pathogenesis of AD, but also to its potential as a therapeutic target and biomarker.
Our Services
- Provide design services for a series of small molecule inhibitors of JNK, and we also provide design services for peptide inhibitors.
- For the above inhibitors, we will optimize them and screen them for you using virtual screening, high-throughput and other methods.
- Provide inhibitor molecular docking (JNK-small molecule inhibitors docking and JNK-peptide inhibitors docking) and molecular dynamics simulation services, and choose suitable simulation conditions such as molecular dynamics simulation force fields for you.
- Provide molecular simulation results analysis services, including but not limited to binding affinity analysis, energy analysis, binding mode analysis, hydrogen bond analysis, etc.
- Help you find genes related to JNK regulation and provide JNK regulation-related gene network analysis, including related gene co-expression network analysis, related microRNA and target gene network map services, related transcription factor analysis and network construction services.
Provided by Clients
Please inform us of the details about your JNK targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- Target small molecule inhibitors design results
- Target peptide inhibitors design results
- Virtual screening results
- High-throughput screening results
- Raw data of molecular dynamics results
- Raw data of molecular docking results
- Other calculation and analysis results
- Gene co-expression network analysis results
- microRNA and target gene network map results
- Related transcription factor analysis results
Our advantages
CD ComputaBio provides you with a variety of target analysis service types for you to choose from. Our experts have extensive experience in this field and have successfully completed multiple projects.
We will complete your project on time and efficiently. We have professional after-sales service: to provide customers with efficient solutions.
Our researchers can quickly understand the project situation through simple descriptions, and quickly formulate feasible research plans based on customer needs.
If you want to know more about JNK targeting services provided by CD ComputaBio, please contact us at any time.
Reference:
- Xuan, Cheng, Zhang, et al. Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics. BioMed research international, 2015.
* For Research Use Only.
