SIRT1 is a member of the Sirtuins family derived from mammals. It is a deacetylase that relies on nicotine adenine dinucleotide. It participates in the regulation of various cellular functions through a reversible acetylation-deacetylation cycle, such as Anti-oxidant stress, anti-infection, anti-apoptosis, pancreatic islet secretion, gene transcription, etc. Sirt1 can regulate mitochondrial biosynthesis and metabolism, repair mitochondrial loss, maintain mitochondrial homeostasis, and is can also inhibit the active pathway of cyclooxygenase, reduce inflammation, and play a certain protective effect on nerve damage.
The effective treatment of AD is still being actively explored, and the effects of SIRT1 in calorie restriction, neuroprotection and regulation of vascular endothelial cell regeneration have received extensive attention and some significant results have also been achieved in AD research. Silent Information Regulator-1 (SIRT1) is a DNA~+-dependent protein acetylase that exists in mammals, mainly located in the nucleus. It can increase the secretion of α-secretase by activating the α-secretase gene ADAM10 and reduce the pathological accumulation of toxic β amyloid precipitation (Aβ). Activated SIRT1 can protect neurons through p25 or SOD1-G37R and maintain normal learning. Memory function and it can interfere with the pathogenesis of AD by affecting energy metabolism.
Our Services
- SIRT1 can reduce pathological accumulation of toxic β amyloid precipitation (Aβ), thus we can provide agonist design services to meet your scientific research needs.
- For the above agonists, we will screen out some dominant ligands for you through molecular docking and high-throughput screening.
- Provide structure optimization and energy minimization services for selected advantageous ligands.
- Provide molecular dynamics simulation and molecular docking services between agonists and SIRT1, and select suitable molecular dynamics simulation conditions for you.
- Provide biological network analysis services, including but are not limited to protein-protein interaction network, amino acid interaction network, metabolic network, gene/transcription regulation network and other services. Our biological network analysis service has high accuracy.
- Provide relevant result analysis services.
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Use statistical techniques to process data and analyze results.
Provided by Clients
Please inform us of the details about your SIRT1 targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- Design of the original structure of small molecule agonist
- Molecular docking score and other related data analysis results
- High-throughput screening results
- The initial structure of the simulation system
- Raw data of molecular dynamics results
- Molecular dynamics analysis results
- Protein-protein interaction network analysis results
- Amino acid interaction network analysis results
- Metabolic network analysis results
- Gene/transcription regulation network analysis results
Our advantages
- CD ComputaBio has successfully completed multiple target calculation services, providing different industry solutions for drug discovery.
- You can inform us of the design demand according to your own scientific research needs, or you can choose the appropriate calculation method according to your own needs. We will provide one-stop professional computational biology services.
- We have strict quality control at every step of the target analysis service to ensure that our customers receive high-quality data.
If you want to know more about SIRT1 targeting services provided by CD ComputaBio, please contact us at any time.
* For Research Use Only.
