Biological systems are often represented as networks of complex sets of binary interactions or relations between different entities. Essentially, every biological entity has interactions with other biological entities, from the molecular to the ecosystem level, providing us with the opportunity to model biology using many different types of networks such as ecological, neurological, metabolic or molecular interaction networks. Systems biology aims to understand biological entities at the systemic level, analyzing them not only as individual components, but also as interacting systems and their emergent properties. Related to this is network biology which allows the representation and analysis of biological systems using tools derived from graph theory.
The network's diameter (the maximum number of steps separating any two nodes) is small, regardless of the network size. This usually means that any two nodes are separated by less than six steps, more or less, reflecting the now widely popularised “six degrees of separation” theory used in social sciences.
The majority of nodes (proteins) in scale-free networks have only a few connections to other nodes, whereas some nodes (hubs) are connected to many other nodes in the network.
The transitivity or clustering coefficient of a network is a measure of the tendency of the nodes to cluster together. High transitivity means that the network contains communities or groups of nodes that are densely connected internally.
|Project name||Network analysis services in biology|
|Samples requirement||Our network analysis services in biology require you to provide specific requirements.|
|Timeline||Decide according to your needs.|
|Deliverables||We provide you with raw data and modeling results.|
Genes and transcription factors are represented as nodes, while the relationship between them is depicted by different types of directional edges.
CD ComputaBio provides corresponding network analysis services in biology. Our network analysis services in biology have proven to be very useful for understanding the biochemical basis of physiological events at different stages of drug development (even in different fields such as materials science). CD ComputaBio team has been working in this field for more than ten years and has published his findings in top scientific journals. If you have a need for network analysis services, please feel free to contact us.
Degree: A degree of a node is a number of edges in a network that connect node with its neighbors.
Connectivity: A connectivity represents minimum number edges that need to be removed to make a disconnected graph.
Shortest path: A shortest path is a path in which the two nodes are connected by the smallest number of intermediate nodes.
Closeness: A closeness centrality of a node is the reciprocal of the average shortest path length.
Betweenness centrality: A betweenness centrality of a node is the number of times that a node is included in the shortest path between each pair of nodes, normalized by the total number of pairs.
Network analysis may help in choosing the right pose in protein-protein docking, which is important for selecting inhibitor binding sites.
Network analysis facilitates the search for variable conformation sites and the study of the mechanism of intra-protein signaling.
The development of protein-protein interaction inhibitors is a promising approach to drug design, and networks demonstrate their suitability for this purpose.
A: You just need to provide us with the raw files of molecular dynamics simulations, and we can perform network analysis services. If you do not have the relevant trajectory files, we also provide a one-stop analysis service including molecular dynamics simulations. If the calculation demand is clear, you can directly choose the corresponding project on the CD ComputaBio website to make an appointment, and you need to fill in the specific calculation materials and calculation requirements when making an appointment. If you are not sure of the calculation content, you can contact the staff directly for demand communication.
A: Through our network analysis services, we can also provide the following data mining services:
A: We offer you the folloing network analysis services for you to choose from:
A: With our network analysis service, you can apply the results to the following areas:
A: CD ComputaBio is one of the leading computational biology companies in the world, is now open to provide web analysis services to our clients. With years of experience in the field of bioinformatics, we are ready to provide our clients with the most outstanding service!