Understanding the dynamic interactions between proteins and DNA is fundamental to elucidating the mechanisms underlying gene regulation, development, and disease, as these interactions govern how genetic information is read, interpreted, and ultimately expressed in living organisms. ChIP-Seq (chromatin immunoprecipitation sequencing), combining chromatin immunoprecipitation and next-generation sequencing, profiles these interactions across the genome. CD ComputaBio provides advanced ChIP-Seq services for high-quality epigenomics data.
Introduction to ChIP-Seq
ChIP-Seq (chromatin immunoprecipitation sequencing), which refers to the binding site analysis, is a way to analyze DNA-protein interactions. The method combines chromatin immunoprecipitation (ChIP) with NGS to identify where the DNA binds to the associated proteins. It can be used to pinpoint the binding sites of any interested protein throughout the genome. ChIP-seq is often used to determine how transcription factors and other chromatin-related proteins affect phenotypic mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential to fully understand many biological processes and disease states.
Figure 1. Chromatin immunoprecipitation sequencing.
Our Services
With state-of-the-art methods and a team of seasoned experts, CD ComputaBio offers unparalleled insights into the complex world of ChIP-Seq.
Workflow of ChIP-Seq Analysis
Project Design: We start by ingesting the ChIP-Seq raw data. Our experts then conduct an initial quality control (QC) assessment, checking for basic parameters such as sequencing depth, read length distribution, and the presence of adapter contaminants.
Bioinformatics & Data Analysis: Comprehensive analysis begins with quality assessment and read alignment, progresses through precise peak calling and motif identification, and extends to advanced differential binding analysis and multi-omics integration.
Integration with Other Omics Data: To gain a more comprehensive understanding of the biological processes, we integrate ChIP-Seq data with other omics data, such as RNA - Seq or DNA methylation data. This multi - omics integration allows for the identification of regulatory networks.
Types of ChIP-Seq Service
Histone Modification ChIP-Seq Services
Identify histone modification profiles on a genome-wide scale.
Transcription Factor ChIP-Seq Services
Genome-scale analysis of transcription factor binding sites.
RNA Polymerase II ChIP-Seq Services
Measure transcription rates across the genome.
DNA Modification ChIP-Seq Services
Advanced ChIP-Seq strategy helps analysis DNA modification.
Super-Enhancer Analysis Services
Bioinformatics approach to identify master regulators of gene expression.
FFPE Sample ChIP-Seq Services
Obtain high-quality ChIP-Seq data from valuable clinical FFPE samples.
Our Advantages
Fast Turnaround & Reliable Support
Efficient project management ensures adherence to clear timelines, while dedicated technical support assists at every stage—from experimental design to data analysis. Researchers benefit from prompt communication and troubleshooting to streamline their studies.
Cost-Effective Solutions
Flexible service packages cater to diverse budgetary needs without compromising data quality. Transparent pricing structures eliminate hidden costs, making high-quality ChIP-Seq accessible for academic and industrial research alike.
Cutting-Edge Technology & Expertise
CD ComputaBio employs state-of-the-art NGS platforms and rigorously optimized ChIP protocols to deliver high sensitivity and specificity in protein-DNA interaction studies. The team's expertise extends to challenging sample types, including low-input and FFPE-derived chromatin
CD ComputaBio's ChIP-Seq services offer a comprehensive, high-quality solution for researchers interested in studying protein-DNA interactions. With its advanced technologies, experienced team, and commitment to customer satisfaction, CD ComputaBio is well-positioned to support a wide range of research projects and contribute to the advancement of genomics research. If you are interested in our services or have any questions, please feel free to contact us.
* For Research Use Only.
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