The homology modeling method is the most widely used protein prediction method. Homology modeling predicts the three-dimensional structure of target proteins based on template proteins. For proteins without experimental crystal structures, homology modeling is undoubtedly an important and effective auxiliary method. The constructed protein model can also be used for subsequent molecular mechanism exploration. Source modeling is a practical method for predicting structure from sequences. There are two prerequisites for this method: First, there are one or several distinguishable structures in the homologous protein of the target sequence. Second, the homology between the target sequence and the protein is high.
|Project name||Homology modeling services|
|Samples requirement||Our homology modeling service requires you to provide specific requirements.|
|Timeline||Decide according to your needs.|
|Deliverables||We provide you with raw data and modeling results.|
CD ComputaBio provides high-quality homology modeling services. The results can help researchers understand the structural properties of the target protein, analyze its "structure-function" relationship, and can be used for drug screening, discovery of potential therapeutic drugs for a disease, or study the interaction between the target and drug. If you need protein structure modeling service, please feel free to contact us.
Homology modeling is a general term for the conversion of primary sequences into 3D structures based on template proteins. It is currently the most effective method for protein three-dimensional structure prediction, and is widely used because of its simplicity, efficiency and high accuracy. According to the theory that the conservativeness of the three-dimensional structure of homologous proteins exceeds the protein sequence, under the premise that the identity of the protein sequence is greater than 30%, proteins with unknown structures can use one or more related structures to construct their three-dimensional structure. We provide a variety of protein structure modeling, but not limited to:
A: If there is sequence, structural and functional homology between an unknown structural protein A and a known structural protein B, then protein A can be used as a template for protein B to build its all-atomic three-dimensional structure. Protein 3D structures are an important basis for understanding their biological functions and for structure-based drug design. With the rapid development of structural biology, the speed of measuring protein 3D structures using methods such as NMR or X-Ray crystallography has been greatly improved. However, the 3D structures of some proteins are still difficult to determine due to many reasons, such as excessive molecular weight or difficulty in crystallization. Such scenarios necessitate the use of computational simulations to construct the three-dimensional structures of proteins. Among the many computer modeling methods, homology modeling is one of the most technically mature, accurate and reliable means.
A: Prediction is divided into ab initio prediction and homology modeling. The accuracy of homology modeling prediction is higher than that of ab initio prediction, although it is still not as accurate as the real measurement. By analyzing the predicted structures, many information can be obtained, such as explaining the catalytic mechanism of enzymes or predicting the mutation sites of proteins, inferring the relationship between protein structure and function, etc.
A: If the modelling needs are clear, you can make an appointment directly on the CD ComputaBio website by selecting the appropriate project. When making an appointment, you need to fill in the specific modelling requirements and provide the protein sequence. If you are not sure about the content of the calculation, you can contact the staff directly to communicate your requirements.
A: We provide high-quality homology modeling services, the results of which can help researchers understand the structural properties of target proteins and analyze their "structure-function" relationships, and can be used for drug screening, discovering potential therapeutic agents for a disease, or studying the interaction patterns of targets and drugs.
A: We will send you the raw data for homology modeling, the original optimized protein structure (pdb file), the optimized protein structure (pdb file), the data analysis results and related image analysis, and the result analysis.
A: Homology modeling include the following process: