SASA (Solvent Accessible Surface Area) Analysis

Solvent accessible surface area (SASA) analysis is an important component of structural biology and biophysical chemistry. It provides an important basis for understanding the molecular interactions, stability and function of proteins, DNA and RNA. Understanding SASA is fundamental to predicting molecular behavior such as ligand binding, protein folding, and protein-protein interactions. With a commitment to excellence, innovation and scientific acumen, CD ComputaBio has become a pioneer in providing advanced analytical services to the scientific and pharmaceutical industries.

SASA analysis is a primary method for studying the behavior and function of biomolecules (such as proteins or nucleic acids) in solution by calculating their surface area in solution. The algorithm we use calculates the surface area of a molecule in solution by performing a fine-grained three-dimensional mesh of each atom of the molecule, including the solvent molecules surrounding it, and summing and integrating over them.

Structural Dynamics Assessment: Our team is adept at elucidating the soluble regions involved in protein-protein, protein-ligand, and protein-nucleic acid interactions, thus contributing to a comprehensive understanding of molecular recognition and binding mechanisms.

Assessment of molecular interactions: By combining SASA analysis with molecular dynamics simulations, we provide in-depth assessments of conformational changes and structural dynamics, which are critical for understanding macromolecular behavior under physiological conditions.

SASA-based Protein Interaction Analysis Service: Using SASA data, we can reveal protein-protein and protein-ligand interactions, and reveal when, where, and how these interactions affect biological functions.

Hydrophobic and Hydrophilic Properties Analysis Service: Through SASA analysis, CD ComputaBio can help clients gain insight into the hydrophobic and hydrophilic properties of molecules, revealing their behavior in an aqueous environment and providing important data for drug design, protein engineering, and structure elucidation.

• Analysis Reports: used to present SASA's computational results, research findings, and possible explanatory scenarios.
• Raw computational and simulation data for further research and analysis by the client.
• Data graphs and live simulation animations tailored to the client's specific needs.

CD ComputaBio's SASA analysis service can help you deeply understand the behavior of molecules in solvents and their functions in molecular interactions, providing accurate data to support your research. Our professional team provides you with the best service with a scientific attitude and rigorous method, and your satisfaction is our highest pursuit. Contact us now for more details on our services!