Caspase 9 Targeting Services
CD ComputaBio now offers professional Caspase 9 targeting services using computational approaches to meet your research needs.
Caspase-9 is an enzyme encoded by the CASP9 gene in humans. It is an initiator caspase essential for apoptotic pathways found in many tissues. Proper caspase-9 function is required for apoptosis, leading to normal development of the central nervous system. Caspase-9 has a variety of additional cellular functions independent of its role in apoptosis. Non-apoptotic roles of caspase-9 include regulation of necroptosis, cellular differentiation, innate immune responses, sensory neuron maturation, mitochondrial homeostasis, corticospinal circuit organization, and ischemic vascular injury. Without proper function, abnormal tissue development occurs, leading to dysfunction, disease, and premature death. Caspase 9 is an important initiating protease in the mitochondria-dependent apoptosis pathway of cells. When stimulated by apoptotic signals, mitochondria release cytochrome C and combine with intracellular caspase activator to form apoptotic bodies, activate caspase-9, activate downstream effector cysteine proteases, and initiate apoptosis. Studies have shown that caspase-9 is widely expressed in human normal tissues, and its expression level is down-regulated in cervical cancer and other tumors.
Our Services
- Statistical Analysis Service
Focus on providing customers with data analysis and statistical services, and the exploration will never end. We fully meet customer data collection and integration needs. We can achieve rapid access to full-link data, break data silos, gain insight into business from multiple perspectives, realize intelligent data decision-making, flexible and multi-dimensional analysis, support multi-level data drilling, and meet multi-scenario analysis needs.
- Redundancy Analysis
- Venn Diagram Service
- Canonical Correspondence Analysis
- Post-translational Modification Service
CD ComputaBio provides PTM computational modeling, which we use to predict potential PTM sites in proteins using computational modeling, and to model side-chain and main-chain conformations to reflect changes caused by common PTMs, representing represents another attractive approach with accuracy, speed and convenience. We offer computational PTM services to help study the corresponding effects on Caspase 9 structure, kinetics, and binding specificity.
-
Data Visualization Service
Our data visualization services are the best way to deal with complex data. We help companies turn their rich data into actionable insights and advise on how to use real-time data to maintain a competitive advantage. We analyze the current reporting structure, identify areas for improvement and fixes using specific metrics, and gather details to meet real-time reporting needs. CD ComputaBio provides you with data visualization services using advanced software tools.
Our Capabilities
CD ComputaBio has an advanced target computing service platform. We will tailor a one-stop targeting service in a high-quality manner to help you achieve your goals and make informed project decisions. Our services will quickly meet your specific needs at very competitive prices. Please feel free to contact us for more details and our scientists will tailor the most reasonable plan for your project. We look forward to working with you to help make your R&D projects a success.
Our Quantum Chemistry Service Targeting Caspase 9
- Quantum Chemistry Service in Drug Design
Quantum chemistry is an indispensable tool in CADD research. High-throughput in silico screening (such as docking or QSAR) for ligand binding can significantly reduce the time required for compound discovery and optimization. However, these fast methods often lack the accuracy to explore the details of the binding mechanism. Our quantum chemistry services mainly include:
- QM/MM Simulation Service
We provide QM computing services to describe the Caspase 9 system, including ligands and solvents, for a more accurate understanding of Caspase 9-ligand interactions. The QM utility provides accurate force field parameters based on ab initio results of small model structures. It can also clearly describe the electronic structure of the molecule.
- Spectrum Prediction Service
We can also predict the UV, IR, and NMR spectra of small molecules using quantum chemical computing software.
* For Research Use Only.
