The protein encoded by the ABCC3 gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across the outer and inner cell membranes. This protein is a member of the MRP subfamily involved in multidrug resistance. The specific function of this protein has not been determined; however, this protein may play a role in the biliary and intestinal excretion of organic anions. Alternative splicing variants encoding different protein isoforms have been described; however, not all variants have been fully characterized. ABCC3 is induced as a hepatoprotective response to a variety of pathological liver diseases. A functional antioxidant response element in intron 8 of the human ABCC3 gene appears to be responsible for Nrf2-mediated induction of oxidative stress. CD ComputaBio now offers professional ABCC3 targeting services to meet your research needs.
Our Services
- Fold Recognition Service
CD ComputaBio provides the expertise to solve your protein folding problems. We help identify the correct structural fold in the known template protein structure of the target protein by combining sequence map alignments with multiple structural information. Our approach starts with the construction of a database/library of structural templates, and then gradually replaces sequences of known protein structures in the library with query sequences of unknown structure. Target sequences can be compared to each structural template through the scoring function of the optimized design. This process will be repeated for all known 3D structures in the template database until the best fit is found.
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Ligand Binding Site Prediction
Our ligand binding site prediction service usually only needs to search the 3D structure of the target protein of the ligand binding site, and through the construction of a web server, prediction tools can be simply used. Additionally, we have developed a large number of bioinformatics tools to predict ligand binding sites, which is the first step towards understanding protein function or facilitating docking calculations in virtual screening-based drug design. CD ComputaBio is proud to provide our clients with the most efficient protein-ligand binding site prediction services.
- Transmembrane Prediction Services
Most of the amino acids that make up transmembrane proteins are hydrophobic amino acids. The transmembrane region of the predicted sequence is essential. Generally, membrane proteins cannot be expressed in prokaryotic expression systems. If the transmembrane region of the sequence is predicted, and there is a transmembrane region in the sequence, a eukaryotic expression system needs to be selected for expression subsequently. CD ComputaBio can provide our clients with the most accurate transmembrane prediction services.
Our Capabilities
CD ComputaBio provides specialized ABCC3 target services. We will complete your project on time and efficiently. We have professional after-sales service: to provide customers with efficient and feasible solutions. We work with scientists from many pharmaceutical and biotech companies. We have extensive knowledge and experience to provide quality assurance services.
Our Drug Design Service Targeting ABCC3
Drug design is the main direction of new drug discovery, and potential drug design targets include enzymes, receptors, ion channels, nucleic acids, etc. Chemical structural features of other ligands or natural products can be used to design rational drug molecules.
Our drug design services include but are not limited to:
- Structure-based Drug Design
- Fragment-based Drug Design
- De Novo Design
- Multiple Targeting Drug Design Services
- Pharmacophore Model Construction Service
- Computer Aided Drug Design Service
* For Research Use Only.
