CD ComputaBio now offers professional Akt2 targeting services using computational approaches to meet your research needs.
AKT2, also known as RAC-beta serine/threonine protein kinase, is an enzyme encoded by the AKT2 gene in humans. It affects the storage of metabolites as part of the insulin signaling pathway. The AKT2 gene is a putative oncogene that encodes proteins belonging to the AKT subfamily of serine/threonine kinases. As part of the insulin signaling pathway, AKT2 has important roles in the control of glycogenesis and glucose transport. The gene was amplified and overexpressed in 2 of 8 ovarian cancer cell lines and 2 of 15 primary ovarian tumors. Overexpression results in a malignant phenotype in a subset of human ductal pancreatic cancers. Mice lacking AKT2 showed worse outcomes in breast cancers triggered by the large T antigen and new oncogenes. AKT2 protein can mediate the phosphorylation of a variety of known proteins involved in the regulation of cell survival, insulin signaling, angiogenesis, and tumorigenesis. AKT2 kinase overexpression caused by AKT2 amplification can be found in ovarian adenocarcinoma, primary ovarian tumors and in well-differentiated ovarian adenocarcinoma. AKT2 gene amplification is associated with resistance to paclitaxel in ovarian cancer cells.
Our Services
- Akt2 Inhibitor Design Service
AKT2 gene amplification and protein overexpression are found in 10-20% of primary pancreatic cancers. That's why we provide AKT2 inhibitor design services to meet your research needs. Our inhibitor design services can be used for feasibility assessment and structure-activity relationship studies of new drug targets. Our computer-aided design service saves a lot of labor costs, the calculation cycle is short, the speed is fast, the funds required are far less than biological or chemical experiments, and the calculation accuracy is high. We provide the following four methods for you to choose from：
- Residue Interaction Network Service
RIN represents a three-dimensional protein structure as a set of nodes (residues) and their connections (edges). Topological parameters calculated from RIN are relevant to various aspects of protein structure and function. We can provide complex analysis of proteins and their complexes and predict different properties and functions of individual residues and whole proteins by using RIN analysis. The chemical and physical properties of bases and the energy of their interactions are analyzed by constructing RINs. Residue interaction network service can be used in the following areas:
- High Throughput Screening Services
We have built an advanced HTS platform to support our clients' research, provide compound design and management automation services, and our screening services include: target-based high-throughput screening and receptor-based high-throughput screening. We built a subset of target libraries containing the most common pharmacologically characterized targets. Our advances in target identification can also characterize the target's pharmacological activity and determine high-throughput feasibility.
Our Capabilities
CD ComputaBio provides specialized Akt2 target services. We will complete your project on time and efficiently. We have professional after-sales service: to provide customers with efficient and feasible solutions. We work with scientists from many pharmaceutical and biotech companies. We have extensive knowledge and experience to provide quality assurance services.
Our Molecular Dynamics Simulation Service Targeting Akt2
Molecular dynamics simulation method mainly relies on Newtonian mechanics to simulate the motion of molecular systems in order to take samples in a system composed of different states of molecular systems, so as to calculate the conformational integrals of the system, and use the results of the conformational integrals as a basis to further calculate the thermodynamic quantities and other macroscopic properties of the system. Depending on the system requirements we can provide.
- All-atom molecular dynamics simulations
In molecular dynamics simulation, the simulation with atoms as the basic unit is called all-atom simulation, and the corresponding model is called all-atom model. All-atom simulations can simulate about 102 to 106 atoms, and the simulation time scale is in the nanosecond range. All-atom simulations mainly study the structural and functional changes of individual biomolecules under different physiological conditions.
- Coarse-grained molecular dynamics simulations
Intracellular interaction processes (such as protein-protein docking, ligand-binding site conformational changes, macromolecular folding, etc.) often involve different types of biomolecules and the collective motion of biomolecules, usually lasting longer than a few microseconds to a few milliseconds, the traditional all-atom simulation is difficult to achieve. Therefore, we reduce the degrees of freedom of the simulated system by simplifying the details of all-atom simulations, giving you a long-term approach to large-scale simulations—the coarse-grain (CG) simulation method.
* For Research Use Only.
