AMPK (Adenosine 5'-monophosphate (AMP)-activated protein kinase), an AMP-dependent protein kinase, is a key molecule in the regulation of bioenergy metabolism. It is expressed in various metabolic-related organs and can be activated by various stimuli of the body, including cell pressure, exercise, and many hormones and substances that can affect cell metabolism. AMPK proteins of different species exist in the form of a heterotrimeric complex, which consists of an α-catalytic subunit, a β-regulatory subunit, and a γ-regulatory subunit. Humans and rodents express two subtypes of α-subunits and β-subunits (α1, α2; β1, β2) and three subtypes of γ-subunits (γ1, γ2, γ3) from different genes.
AMPK is a phylogenically conserved serine/threonine protein kinase, a metabolic sensor expressed in almost all mammalian cell types, which is a new common determinant of neurodegenerative diseases. AMPK Regulates intracellular ATP levels and participates in regulating many downstream targets of various enzymatic pathways (such as lipolysis and glycolysis pathways). After activation, AMPK undergoes a large amount of phosphorylation and down-regulates the number of targets, so AMPK is one of the possible targets of major anti-AD drugs.
Our Services
- Provide design, screening and optimization services for target drugs.
- Provide GO enrichment analysis service. Our GO enrichment analysis is to classify AMPK-related differential genes according to GO, and perform significant analysis according to the discrete distribution of classification results, error rate analysis, and enrichment analysis.
- Provide the pharmacophore service of the target drug, predict the target through the pharmacophore, and predict the pharmacological action spectrum of the compound. By using the pharmacophore model, the possibility of drug development failure can be reduced in drug development.
- Provide the binding site prediction service of the target drug and AMPK.
- Provide molecular docking and molecular dynamics simulation services between target drugs and AMPK.
- Provide relevant results analysis and data statistics services.
- Provide interaction network analysis, which can analyze gene regulation network, amino acid-amino acid interaction, metabolite flow, drug side effect prediction, etc. for you professionally.
Provided by Clients
Please inform us of the details about your AMPK targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- The original structure of designed target drugs
- GO enrichment analysis results
- Binding site prediction results and related residue analysis
- Raw data of molecular dynamics results
- Raw data of molecular docking results
- Raw data of molecular dynamics results
- Other calculation and analysis results
Our advantages
- Equipped with skilled calculation operators, under the premise of ensuring quality, the project can be completed in a short time, and the calculation results are accurate, objective and credible.
- Strict quality control system and simplified experimental procedures ensure high-precision computing services.
- Complete the result analysis, provide a detailed experimental process reports and deliver the product.
- Can provide a true one-stop service experience, saving customers valuable time.
If you want to know more about AMPK targeting services provided by CD ComputaBio, please contact us at any time.
Reference:
- Xuan, Cheng, Zhang, et al. Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics. BioMed research international, 2015.
* For Research Use Only.
