In the early development of antibody drugs, the identification of antibody-antigen binding epitopes is the basic prerequisite for revealing the pharmacodynamic mechanism of antibody drugs. It is of great significance for the subsequent humanization of antibody drugs and antibody affinity maturation, and can accelerate the process of antibody drug development. The antibody homology modeling algorithm has been relatively mature after more than ten years of development. Now, CD ComputaBio offers antibody docking service to meet the specific needs of different customers.
CD ComputaBio can accurately predict the structure of a part of the antibody sequence, and using conventional protein-protein docking prediction algorithms, it can quickly analyze some amino acid interactions at the antibody-antigen binding interface.
CD ComputaBio introduces greater freedom in the docking process through the following four aspects:
CD ComputaBio use SnugDock algorithm to provide you with antibody docking service, which can introduce the concept of "flexibility" between the antibody-antigen molecule and the antibody heavy chain light chain interface. By randomly selecting the above sampling strategy, the "induction fit" in the formation of the antibody-antigen complex is truly realized. effect.
SnugDock's algorithm can improve the accuracy of antigen-antibody docking, making the conformation of near-natural complexes more enriched, and reducing the proportion of false positive structures appearing in the top rankings. Although the imported antibody structure is derived from homology modeling, SnugDock can also effectively reduce the impact of structural errors in the antibody homologous model.
|Project name||Antibody docking service|
|Our services||CD ComputaBio offers antibody docking service to meet the specific needs of different customers.|
|Timeline||Decide according to your needs.|
|Deliverable||We provide you with raw data and analysis service.|
CD ComputaBio provides professional antibody docking service to meet the specific needs of regular customers on time and according to budget. CD ComputaBio relies on world-class technical expertise, we provide customers with the best quality one-stop antibody docking service, including the development of scientific procedures according to different solution needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project. If you want to know more service prices or technical details, please feel free to contact us.