Antibody aggregation remains a major area of concern in monoclonal antibody (mAb) production. Improving the intrinsic properties of antibodies can improve manufacturability, wear rate, safety, formulation, titer, immunogenicity, and solubility. As a leading provider of excellent customized antibody development services, CD ComputaBio provides a wide range of industry-leading antibody design platforms and services to improve antibody stability and reduce antibody aggregation. We can customize the discovery and development path to meet your exact needs.

Overall solutions

CD ComputaBio can infer the thermodynamic aggregation potential from the intrinsic and structural characteristics of the protein/antibody sequence. Therefore, through rational design of protein/antibody sequence and structure, aggregation can be well controlled. Protein unfolding and nucleation are the key steps of protein aggregation, and subsequent monomer addition and aggregation combination occur faster. Therefore, strategies to improve aggregation usually target aggregation stages I, II, and III. The corresponding method to alleviate aggregation is:

• Stabilize natural monomers or destabilize partially unfolded monomers to reduce the possibility of protein unfolding in stage I.
• Change the surface charge distribution to increase the electron repulsion between the unfolded monomers in the second stage.
• Disrupt the structural rearrangement of unfolded monomers in Phase III, which is not conducive to hydrophobic contact and accumulation of β chains.

Algorithm

CD ComputaBio can provide different antibody stability construction methods, such as ZDOCK, RDOCK, Flexible docking. In addition, we can optimize the docking results through molecular dynamics (MD) to obtain a high-precision recognition model.

Why choose us?

• CD ComputaBio has extensive knowledge and experience in antibody stability construction service.
• CD ComputaBio will complete your project on time and efficiently and meet your requirements.
• CD ComputaBio has established a professional after-sales service team to provide customers with efficient, fast, practical and feasible solutions.
• CD ComputaBio has in-depth cooperation with many pharmaceutical companies and research institutes, and has extensive experience in providing them with high-quality services.

Our services

CD ComputaBio provides professional antibody stability construction service to meet the specific needs of regular customers on time and according to budget. CD ComputaBio relies on world-class technical expertise, we provide customers with the best quality one-stop antibody stability construction service, including the development of scientific procedures according to different solution needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project. If you want to know more service prices or technical details, please feel free to contact us.