Antibody aggregation remains a major area of concern in monoclonal antibody (mAb) production. Improving the intrinsic properties of antibodies can improve manufacturability, wear rate, safety, formulation, titer, immunogenicity, and solubility. As a leading provider of excellent customized antibody development services, CD ComputaBio provides a wide range of industry-leading antibody design platforms and services to improve antibody stability and reduce antibody aggregation. We can customize the discovery and development path to meet your exact needs.
CD ComputaBio can infer the thermodynamic aggregation potential from the intrinsic and structural characteristics of the protein/antibody sequence. Therefore, through rational design of protein/antibody sequence and structure, aggregation can be well controlled. Protein unfolding and nucleation are the key steps of protein aggregation, and subsequent monomer addition and aggregation combination occur faster. Therefore, strategies to improve aggregation usually target aggregation stages I, II, and III. The corresponding method to alleviate aggregation is:
CD ComputaBio can provide different antibody stability construction methods, such as ZDOCK, RDOCK, Flexible docking. In addition, we can optimize the docking results through molecular dynamics (MD) to obtain a high-precision recognition model.
|Project name||Antibody stability construction service|
|Our services||CD ComputaBio offers antibody stability construction service to meet the specific needs of different customers.|
|Timeline||Decide according to your needs.|
|Deliverable||We provide you with raw data and prediction results.|
CD ComputaBio provides professional antibody stability construction service to meet the specific needs of regular customers on time and according to budget. CD ComputaBio relies on world-class technical expertise, we provide customers with the best quality one-stop antibody stability construction service, including the development of scientific procedures according to different solution needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project. If you want to know more service prices or technical details, please feel free to contact us.