c-Met, also known as tyrosine protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein encoded by the MET gene in humans. This protein has tyrosine kinase activity. The c-MET signaling pathway can be abnormally activated through various mechanisms, such as c-MET mutation, amplification, overexpression, and HGF overexpression, and is involved in the occurrence and development of non-small cell lung cancer (NSCLC) and epidermis. It plays an important role in the drug resistance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Therefore, c-MET is another molecular therapeutic target for NSCLC after EGFR and ALK. Now, CD ComputaBio offers professional c-MET targeting services to meet your research needs.
Our Services
- Molecular Dynamics Simulation
Providing a one-stop molecular dynamics simulation service, our researchers can obtain the motion trajectories of atoms in the system, and can observe various microscopic details of the atomic motion process, such as the interaction mechanism between c-ME targets and small molecules. At the same time, we also provide corresponding molecular dynamics simulation results analysis services:
- Hydrogen Bond Analysis
- Hydrophobic Force Analysis
- Binding Free Energy (MMGBSA)Analysis
- Binding Mode Analysis Services
- Electrostatic Interaction Analysis Service
- RMSD Analysis Service
- Network Analysis Service
We provide network modeling services using many different types. Our target analysis services not only analyze individual targets as individual components, but also analyze them as interacting systems and their emergent properties.
- Protein-Protein Interaction Networks
- Metabolic Networks
- Gene/Transcriptional Regulatory Networks
- Cell Signalling Networks
- Genetic Interaction Networks
- Cluster Analysis Service
The goal of cluster analysis is to collect biological data for classification on the basis of similarity. We use cluster analysis tools that use k-means, k-centre and other algorithms to provide you with professional cluster analysis services.
Our Capabilities
For many years, we have been providing one-stop computational biology services to the world's leading computational biology companies. We have assembled a team of professionals to work with researchers around the world to meet our clients' needs and ensure the quality of our services.
Our Protein Sequence Analysis Targeting c-MET
Before the biological activity screening, the molecular docking software on the computer is used to simulate the interaction between the target and the candidate drug, and the affinity between the two is calculated to reduce the number of actual screening compounds and improve the efficiency of lead compound discovery. Our virtual screening strategy mainly includes:
- Molecular docking
Through molecular docking between small molecule compounds and targets, the score and spatial conformation are comprehensively analyzed, including electrostatic interaction, hydrogen bond interaction, hydrophobic interaction, van der Waals interaction and other properties.
- Pharmacophore Screening
By analyzing the pharmacodynamic characteristics of one or more active small molecules, Tweener summarizes the important pharmacophore characteristics that make the molecules active. Pharmacophore screening is computationally small and can be performed before molecular docking, and it only takes a short time to perform pharmacophore screening on a database of millions or tens of millions of small molecules.
Project Sample
Our computational biology team has extensive experience in the research of c-MET targets. The following is a small snapshot of our research process for reference only. For details, please feel free to consult our professional team.
* For Research Use Only.
