Cell division protein kinase 8 is an enzyme encoded by the CDK8 gene in humans. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C bind to mediator complexes and regulate transcription through multiple mechanisms. CDK8 binds and/or phosphorylates several transcription factors that can activate or inhibit transcription factor function. CDK8 is a colorectal cancer oncogene: CDK8 gene is amplified in human colorectal tumors and activates β-catenin-mediated transcription that drives colon tumorigenesis. However, CDK8 may not be oncogenic in all cell types and indeed may act as a tumor suppressor in the notch and EGFR signaling pathways. CD ComputaBio now offers professional CDK8 targeting services to meet your research needs.
Our Services
- Enzyme Molecular Dynamics Simulation Service
We use molecular dynamics simulations to predict changes in enzymatic systems over time to explore important biological and pharmaceutical events. Specifically, experimentally determined structures can be improved, enzyme-ligand binding assessed, and biocatalytic processes studied. MD simulations are particularly useful in computer-aided drug discovery. It can be used to identify cryptic or allosteric binding sites, enhance traditional virtual screening methods, and directly predict the binding energies of small molecules. Our service process is as follows:
- Data Visualization Service
Our data visualization services are the best way to deal with complex data. We help companies turn their rich data into actionable insights and advise on how to use real-time data to maintain a competitive advantage. We analyze the current reporting structure, identify areas for improvement and fixes using specific metrics, and gather details to meet real-time reporting needs. CD ComputaBio provides you with data visualization services using advanced software tools.
- Reverse docking service
Reverse docking, which can help identify new disease targets, presupposes a collection of target structures that contain information about potential ligand-binding regions. We will provide the correct construction of the target structure database, which is a key step to improve the accuracy and applicability of the reverse docking method. The researchers selected specific reverse docking tools and servers to meet their specific conditions and purposes. Many studies have used reverse docking as a primary method or as a secondary option for the analysis of broad-spectrum targets associated with small molecules.
Our Capabilities
CD ComputaBio has an advanced target computing service platform. We will tailor a one-stop targeting service in a high-quality manner to help you achieve your goals and make informed project decisions. Our services will quickly meet your specific needs at very competitive prices. Please feel free to contact us for more details and our scientists will tailor the most reasonable plan for your project. We look forward to working with you to help make your R&D projects a success.
Our Protein Structure Modeling Strategy Targeting CDK8
CD ComputaBio uses computational modeling to predict the three-dimensional structure of proteins. We have extensive experience in modeling various proteins. The resulting structural models are all quality-validated and can be used for a variety of purposes, such as annotating genes with unknown functions and structure-based drug design. Structural modeling programs also work seamlessly with downstream computational modeling protocols, including docking and molecular dynamics simulations. Our related services include but are not limited to:
* For Research Use Only.
