IRAK-4 (interleukin 1 receptor-associated kinase 4) belongs to the IRAK family, a family of protein kinases involved in innate immune response signaling from Toll-like receptors. There is evidence that IRAK4 is involved in three components of TLR signaling. First, IRAK4 is the initial kinase in the vicinity of TLR receptors and is used to activate downstream effectors in the inflammatory cascade response, such as cytokines and chemokines. Second, deletion of the IRAK4 gene leads to defects in various cytokine responses, and finally, IRAK4-deficient patients exhibit immunodeficiency to IL-1, IL-8, and other TLR-binding ligands. Considering the downstream location of IRAK4 in these signaling events, it is an important target for drug therapy in various inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease and other autoimmune diseases. CD ComputaBio now offers professional IRAK4 targeting services to meet your research needs.

Our Services

• Statistical Data Analysis and Programming

CD ComputaBio has a dedicated team of structural biologists who can analyze and reconstruct high-resolution macromolecular structures (and their complexes) from X-ray crystallography, NMR, and EM data. CD ComputaBio develops statistical methods for testing, regression, clustering, classification, error rates, resampling, quality control, outlier detection, and programming, and applies them to a wide range of topics in biological research. They are applied to a wide range of topics in biological research. CD ComputaBio works closely with clients to build and maintain research data workflows to help improve scientific reproducibility and scale up complex data analysis tasks.

• Biological Data Management Services

CD ComputaBio provides biological data management services. We use effective data management and data analysis methods to help our clients process a wide range of data and seek to transform raw data into biological knowledge. Our services cover the entire bioinformatics data lifecycle, including the management and monitoring of the ingestion, integrity and use of all types of bioinformatics data.

• Signaling Pathway Analysis

CD ComputaBio provides IRAK4 related signaling pathway analysis. Our services include, but are not limited to, KEGG pathway annotation, KEGG pathway classification, environmental information processing (membrane transport, signal transduction, etc.), and KEGG pathway enrichment analysis.

Our Capabilities

CD ComputaBio offers you a complete range of IRAK4 targeting services. We have established a complete and professional computing platform. We can help design the details of IRAK4 targeting services through rigorous quality control and advanced computational platforms.

Our Pharmacophore Model Construction Service Targeting IL-4

CD ComputaBio provides professional pharmacophore modeling services. Our pharmacophore models can help discover key pharmacodynamic features of drug molecules and establish clear structure-activity relationships. Virtual screening of compound libraries by pharmacokinetic methods finds new scaffold compounds with activity against the target. Pharmacophore models also allow for target prediction and predict the pharmacological spectrum of action of compounds. By using Pharmacophore models, major adverse effects can be predicted early in drug development, thus reducing the probability of drug development failure.