MAPK is an important transmitter of signals from the surface of the cell to the inside of the nucleus. MAPK is a group of serine-threonine that can be activated by different extracellular stimuli, such as cytokines, neurotransmitters, hormones, cell stress, and cell adhesion protein kinase. MAPK is identified because cultured cells are activated when stimulated by growth factors and other mitogens. All eukaryotic cells can express MAPK. The basic composition of the MAPK pathway is a three-level kinase model that is conserved from yeast to humans, including MAPK kinase (MAP kinase, MKKK), MAPK kinase (MAP kinase, MKK), and MAPK, can be activated in turn, and jointly regulate cell growth, differentiation, stress adaptation to the environment, inflammatory response, and many other important cellular physiological/pathological processes.
The latest drug development pipeline focuses on pharmacological targets, including enzymes, receptors and their different signaling pathways. Therefore, studying various AD signaling pathways can help design drug methods that target receptors to combat AD. Different signal transduction and metabolic pathways leading to AD synaptic toxicity and neurodegeneration are receiving full attention and can be used as effective molecular targets. The MAPK subfamily is a potential research target.
Our Services
- Provide MAPK-related signal pathway analysis. Our services include but are not limited to KEGG pathway annotation, KEGG pathway classification, environmental information processing (membrane transport, signal transduction, etc.), and KEGG pathway enrichment analysis.
- Provide protein-protein simulation services to help you study the details of the interaction between MAPK and other targets.
- Provide biological data management services, we use effective data management and data analysis methods to help customers process various data, and strive to convert raw data into biological knowledge. Our services cover the entire bioinformatics data life cycle, including management and monitoring of the intake, integrity and use of various types of bioinformatics data.
- Provide protein-protein interaction network analysis service. Establish highly specific physical contact between MAPK and other protein molecules through the interactions. They include electrostatic forces, hydrogen bonding, and hydrophobic interactions.
- Provide molecular dynamics simulation that studies the details of the interaction between small molecules and MAPK.
- Provide corresponding result analysis service.
Provided by Clients
Please inform us of the details about your MAPK targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- KEGG enrichment analysis results
- Raw data and result analysis of protein-protein dynamics results
- Protein-protein interaction network diagram and result analysis
- Biological data management result analysis
- Other calculation and analysis results
Our advantages
CD ComputaBio has professional target analysis experts. They have accumulated many years of experience in the field of computational biology and provide you with customized solutions.
We have successfully supported multiple target analysis and analysis service projects. Our team has deep scientific literacy and years of industry experience, which can bring deeper and deeper professional knowledge and rich experience to customers.
CD ComputaBio will complete your project on time and efficiently. We have professional after-sales service: to provide customers with one-stop solutions.
If you want to know more about MAPK targeting services provided by CD ComputaBio, please contact us at any time.
Reference:
- Xuan, Cheng, Zhang, et al. Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics. BioMed research international, 2015.
* For Research Use Only.
