Melanocortin 1 receptor (MC1R) is a G protein-coupled receptor that binds to pituitary peptide hormones for melanocortin, including adrenocorticotropic hormone (ACTH) and various forms of melanocyte-stimulating hormone (MSH). MC1R is one of the key proteins involved in the regulation of mammalian skin and hair color. It is located on the plasma membrane of specialized cells called melanocytes, which produce melanin through the process of melanogenesis. It works by controlling the type of melanin produced, and its activation causes melanocytes to switch from the default production of yellow or red pheomelanin to the alternative brown or black eumelanin. A single nucleotide polymorphism in MC1R associated with susceptibility to non-melanoma skin cancer. Variants of MC1R, even in heterozygotes and independent of their effect on pigmentation, have been reported to be risk factors for basal cell carcinoma and squamous cell carcinoma. CD ComputaBio now offers professional MC1-R targeting services to meet your research needs.

Our Services

• Homology Modeling Service

CD ComputaBio's homology modeling services can help researchers understand the structural properties of target proteins and can be used for drug screening, discovery of potential disease treatments, or target-drug interaction studies. Homology modeling is a practical method for predicting structure from sequences. There are two prerequisites for this approach: First, the presence of one or several distinguishable structures in the homologous protein of the target sequence. Second, the homology of the target sequence to the protein is high.

• Protein Sequence Analysis Service

CD ComputaBio can provide you with a wide range of protein sequence analysis services. We provide protein sequence analysis by classifying proteins into protein families and predicting structural domains and significant sites. Our prediction methods include Bayesian network method, support vector machine, Hidden Markov model, artificial neural network method, regression analysis and alignment-free sequence analysis.

• Biological Model Service

Customized data analysis services are becoming more and more important in the field of biological sciences and undoubtedly help to speed up the research cycle. CD ComputaBio integrates differential analysis of experimental data, providing an efficient means to analyze complex systems with potential for biomedical applications.

Our Capabilities

CD ComputaBio offers you a complete range of MC1-R targeting services. We have established a complete and professional computing platform. We can help design the details of MC1-R targeting services through rigorous quality control and advanced computational platforms.

Our Computational Peptide Strategies Targeting MC1-R

We provide professional computational peptide services. In addition to designing small molecule inhibitors for you, we can also provide peptide inhibitor design services, subsequent peptide molecular dynamics simulation and result analysis services. Specifically, our computational peptide services include, but are not limited to: