Musashi-1 Targeting Services
The RNA-binding protein Musashi homolog 1, also known as Musashi-1, is a protein encoded in humans by the MSI1 gene. This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA-binding protein involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation. Overexpression of this gene has been associated with malignancy and proliferative activity in gliomas and melanomas. Increased expression of MSI1 protein was observed in endometriosis and endometrial cancer siRNA-mediated suppression of MSI expression in endometrial cancer cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway.MSI1 is highly expressed in neural progenitor cells and is required for normal brain development. Mutations in these genes are responsible for autosomal recessive primary microcephaly. CD ComputaBio now offers professional Musashi-1 targeting services to meet your research needs.
Our Services
- Ligand Binding Site Prediction
We can predict the ligand-binding site from the structure of Musashi-1. Identifying ligands or small molecules that can bind to targets is also an important clue for predicting protein function. Ligands and other small molecules can be determined directly within the protein's 3D structure, or the ligand binding site can be predicted using the protein's 3D structure, helping to annotate the protein.
- Reverse Virtual Screening
Reverse virtual screening methods hold significant promise in the areas of drug target identification, new use of old drugs, and drug side effect/toxicology studies. It has attracted a lot of attention from researchers in the field of drug discovery. CD ComputaBio provides services using a variety of internationally recognized and industry leading drug design software. We integrate multiple methods such as receptor-based, ligand-based and data-based methods to obtain the most accurate screening results
- 3D-QSAR Service
3D-QSAR is a method that introduces three-dimensional structural information of drug molecules for quantitative conformational relationship studies. This method indirectly reflects the non-bonded interaction properties of drug molecules and macromolecules in the interaction process. Since 2D QSAR has clearer physical meaning and richer information, the most widely used 3D QSAR methods are CoMFA and CoMSIA, i.e., comparative molecular field method and comparative molecular similarity method.
Our Capabilities
CD ComputaBio offers you a variety of target analysis service types to choose from. Our experts have extensive experience in the field and have successfully completed several projects. We will complete your project on time and efficiently. Our researchers can quickly understand the project situation through a simple description, and quickly develop a feasible research plan according to customer needs. If you would like to know more about the Musashi-1 targeting services provided by CD ComputaBio, please feel free to contact us.
Our Protein Structure Modeling Service Targeting Musashi-1
CD ComputaBio uses computational modeling to predict the three-dimensional structure of proteins. We have extensive experience in modeling various proteins. The resulting structural models are all quality-validated and can be used for a variety of purposes, such as annotating genes with unknown functions and structure-based drug design. Structural modeling programs also work seamlessly with downstream computational modeling protocols, including docking and molecular dynamics simulations. We provide the following protein structure modeling services for you to choose from:
* For Research Use Only.
