Presenilin Targeting Services
Presenilin is a family of related multi-transmembrane proteins that act as part of γ-secretase intramembrane protease complex. There are two presenilin genes in vertebrates, called PSEN1 (located on human chromosome 14), which encodes presenilin 1 (PS-1) and PSEN2 (on human chromosome 1) encodes presenilin 2 (PS-2). Both genes show conservation between species, and the difference between rat and human presenilin is very small. Presenilin cuts in the α-helix region of one of the cytoplasmic loops, resulting in a large N-terminal and a smaller C-terminal fragment, which together form part of the functional protein. The cleavage of presenilin 1 can be prevented by mutations that cause the loss of exon 9 and result in loss of function.
Presenilin is the catalytic component of the γ-secretase complex with multiple biological activities, and promotes the pathogenesis of AD through the "amyloid hypothesis". APP and Notch (type I transmembrane cell surface receptors) are important γ-secretase substrates. Among them, presenilin plays an important γ-secretase-dependent role in the sequential cleavage of APP and Notch. PS mutations leads to damage to the Notch signaling pathway, which plays an important role in neurogenesis. From a genetic point of view, presenilin, the early-onset gene and the late-onset gene apolipoprotein E (ApoE), significantly increased the accumulation of amyloid plaques in the AD brain.
Our Services
- Presenilin has been proven to promote the pathogenesis of AD, we can provide presenilin inhibitor design services to meet your scientific research needs. Our design methods include structure-based design and fragment-based design.
- Provide multiple targeting inhibitor design services. The advantage of multiple targeting drug design technology is to provide new ideas for the development of new drugs, make full use of the structural information of known compounds.
- For the above inhibitors, we will screen out a series of advantageous ligands for you through virtual screening and structural optimization.
- Provide one-stop pharmacophore model construction services, which can help discover the key characteristics of inhibitor molecules and establish a clear structure-activity relationship.
- Provide professional 3D-QSAR services. Our overall solutions include data mining methods and matched molecular pair analysis.
- Provide molecular dynamics simulation and molecular docking services between inhibitors and presenilin.
- Provide relevant result analysis services.
- Use statistical techniques to process data and analyze results.
Provided by Clients
Please inform us of the details about your presenilin targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- The original structure of designed presenilin inhibitors
- Multiple targeting inhibitor design results
- Raw data of molecular dynamics results
- Molecular dynamics analysis results
- Pharmacophore model construction results
- 3D-QSAR analysis results
Our advantages
- With advanced modeling and bioinformatics software, our team is committed to providing customers with a full range of target analysis support.
- We have strict quality control on every step of presenilin targeting services to ensure that our customers obtain high-quality data.
If you want to know more about presenilin targeting services provided by CD ComputaBio, please contact us at any time.
* For Research Use Only.
