Common functional analysis methods for genes include metabolic signaling pathways and GO (gene ontology) analysis. In addition, there are COG (Clusters of Orthologous Groups of proteins), protein domain (protein domain), and other analyses. The application of functional analysis is very common. Taking pathway analysis as an example, its related documents are increasing year by year. Therefore, gene function analysis is a prevalent and important analysis content. GO mainly studies gene function, while pathway studies gene and protein function. GO functions are mainly divided into three categories: BP (Biological process), MF (molecular function) and CC (cell composition); among them, the most commonly used is GO BP analysis. Common pathway data includes KEGG, Reactome, Biocarta, etc.

Overall solutions

Functional analysis is mainly divided into two categories: functional annotation analysis and functional enrichment analysis.

Functional annotation consists of three main steps:

• Identifying portions of the genome that do not code for proteins.
• Identifying elements on the genome, a process called gene prediction.
• Attaching biological information to these elements.

The general steps of enrichment analysis provided by CD ComputaBio are summarized below:

• Calculate a p-value that represents the amount to which the proteins in the set are over-represented at either the top or bottom of the list.
• Evaluate the statistical significance of a node or pathway based on the p-value.
• P-value for each set is normalized and a false discovery rate is calculated for multiple hypothesis testing.

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Applications

• Cancer Profile
• Complex diseases (such as schizophrenia)
• Depression
• Spontaneous preterm birth
• Genome-wide association studies

Related Services:

• KEGG Pathway Annotation and Enrichment Analysis Service
• KEGG Enrichment Analysis Service

CD ComputaBio' gene function annotation and function enrichment analysis can reduce the cost of later experimental screening. Gene function annotation and function enrichment analysis is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us.