High-Precision Protein Comparison Modeling

The analysis of protein structure is crucial to the understanding of its function. However, due to the limitations of technical means, the use of experimental methods (mainly X-ray, NMR) to analyze protein structure requires a large investment, a long cycle, and a high risk. Therefore, we need a simple, fast and relatively accurate technique to determine the spatial structure of proteins. Protein modeling technology can solve the above problems very well. This method uses the means of information technology to directly predict the high-level structure (mainly tertiary structure) of the protein from the primary structure (amino acid sequence) of the protein. Now, CD ComputaBio offers high-precision comparison modeling service to meet the specific needs of different customers.

Overall solutions and process

  • Our protein high-precision comparison modeling service is suitable for using the structure of single or multiple template proteins to predict the homologous structure of the target protein.
  • The coverage of the template is limited. CD ComputaBio will extract the conserved regions and complete the missing parts to form a structural model with a complete amino acid sequence.
  • CD ComputaBio uses efficient sampling methods and all-atom force field parameters to optimize the model, and output high-precision homology models.
  • Calculation principle

The algorithm is a process of Monte Carlo assembling and optimizing multiple template fragments starting from a randomly selected template. The Monte Carlo optimization process includes the following parts:

  • Insert Fragment in the non-homologous part
  • Use different template structures for coordinate substitution for randomly selected parts
  • Use smooth Rosetta centroid energy function for Cartesian space optimization
  • Finally, all atomic optimizations are performed.

Why choose us?

  • CD ComputaBio has extensive knowledge and experience in high-precision protein comparison modeling service. We have collaborated with many biotech companies and many scientists in research institutes. We have rich experience in this area to meet your scientific research needs.
  • CD ComputaBio has in-depth cooperation with many pharmaceutical companies and research institutes, and has extensive experience in providing them with high-quality services.
  • CD ComputaBio will complete your project on time and efficiently and meet your requirements.
  • CD ComputaBio has established a professional after-sales service team to provide customers with efficient, fast, practical and feasible solutions.

Our services

Project name High-precision protein comparison modeling
Our services CD ComputaBio offers high-precision protein comparison modeling service to meet the specific needs of different customers.
Timeline Decide according to your needs.
Deliverable We provide you with raw data and analysis service.
Price Inquiry

CD ComputaBio provides professional high-precision protein comparison modeling service to meet the specific needs of regular customers on time and according to budget. CD ComputaBio relies on world-class technical expertise, we provide customers with the best quality one-stop high-precision protein comparison modeling service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project. If you want to know more service prices or technical details, please feel free to contact us.

* For Research Use Only.

Inquiry

logo

CONTACT US

© 2021 CD ComputaBio. All rights reserved.