Post-translational modification refers to the chemical modification of a protein after translation. For most proteins, this is a later step in protein biosynthesis. The precursor protein is inactive, and a series of post-translational processing is often required to become a functional mature protein. There are many types of processing, generally divided into the following types: N-terminal fMet or Met excision, disulfide bond formation, chemical modification and shearing. When synthesizing protein, 20 different amino acids are combined into protein. After the translation of the protein, other biochemical functional groups of the protein (such as acetate, phosphate, different lipids and carbohydrates) will be attached to the protein to change the chemical properties of the protein, or cause structural changes (such as the establishment of disulfide Key) to broaden the function of proteins. Here, CD ComputaBio's bioinformatician can offer you PTM predictions service to meet the specific needs of different customers.
Phosphorylation: signal transduction, cell cycle, growth and development and cancer mechanisms, etc.
Glycosylation: protein folding, renewal and immune response, etc.
Acetylation: regulation of gene expression, apoptosis, cell metabolism, protein stability, neurodegenerative diseases, etc.
Ubiquitination: cell cycle, apoptosis, transcription regulation, DNA repair and signal transduction, etc.
Methylation: chromatin structure and transcription regulation, etc.
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CD ComputaBio' PTM predictions service can significantly reduce the cost and labor of the subsequent experiments. PTM predictions service is a personalized and customized innovative scientific research service. Each project needs to be evaluated before the corresponding analysis plan and price can be determined. If you want to know more about service prices or technical details, please feel free to contact us.