GSK- 3β Targeting Services
Glycogen Synthase Kinase-3 (GSK-3) is an evolutionarily conserved serine/threonine kinase that is ubiquitous in mammalian eukaryotic cells. In addition to the earliest discovered regulation of glycogen synthase (GS) activity, GSK-3β can also act on numerous signal structural proteins and transcription factors to regulate cell differentiation, proliferation, survival and apoptosis. In the research of cancer, neurodegenerative diseases, neuropsychiatric diseases and many other major diseases, its selection as a therapeutic target has attracted more and more researchers' attention.
Alzheimer’s disease is currently the most common type of dementia. It is an irreversible neurodegenerative disease that can cause loss of memory and behavior, as well as personality changes. There are two main symptoms, namely amyloid plaques and neurofibrillary tangles (NFTs), they are found in the brains of patients with Alzheimer's disease. Phosphorylation of tau protein by GSK-3β protein will promote the formation of NFTs, which play a very important role in Alzheimer's disease. Therefore, inhibiting the activity of GSK-3β protein will be a way to treat Alzheimer's disease.
Our Services
- Provide professional drug design services, including structure-based drug design, fragment-based drug design and de novo design.
- Provide GSK-3β inhibitor design services, we offer you with small molecule inhibitors or peptide inhibitors, you can choose according to your scientific needs.
- Provide corresponding computational peptide services, including peptide drug binding affinity calculation service, peptide drug target verification service and peptide drug energy calculation service.
- Provide one-stop protein fold recognition services, high-precision protein comparison modeling service and protein physico-chemical property measurements services.
- Provide a variety of network analysis services, including residue interaction network services, PPI network services and gene co-expression network analysis.
- Provide comprehensive biological data analysis services to discover new knowledge from various types of biological data, including biological model services, statistical data analysis and programming and data visualization services.
- Provide related bioinformatics services, including gene function annotation and function enrichment analysis services, bioinformatics analysis-data preprocessing and normalization services, and bioinformatics data management services.
Provided by Clients
Please inform us of the details about your GSK-3β targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- Drug design results and related data analysis
- Raw data of fold recognition results
- GSK-3β inhibitor design results
- High-precision protein comparison modeling results
- Protein physico-chemical property measurements results
- Network analysis results
- Gene function annotation and function enrichment analysis results
- Bioinformatic analysis-data preprocess and normalization analysis results
- Bioinformatics data management service analysis results
- Other calculation and analysis results
Our advantages
- CD ComputaBio's expert team has many years of experience in the field of computational biology, and they have a multidisciplinary background, including medicine, pharmacy, molecular biology, etc. They attach great importance to innovation and practice.
- We collaborate with scientists from many pharmaceutical and biotech companies. We pay special attention to target analysis related services and are committed to contributing to more customers.
- We will complete your project on time according to your scientific research needs. We have a strict quality management system to provide customers with efficient and reliable solutions.
If you want to know more about GSK-3β targeting services provided by CD ComputaBio, please contact us at any time.
* For Research Use Only.
