Recombinant Human DYRK1A Protein (aa 674-763), GST-tagged

Product Details

Catalog

CPB-B021

Product Name

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

UniProt

Q13627

Type

KINASES PROTEINS

Description

High purity crystallization grade drug target recombinant proteins are ready to be shipped to customers for research purposes. The proteins have been purified to a high degree, characterized and crystallized.

Origin

Human

Source

Wheat Germ

Gene Information

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Synonyms

DYRK, MNB, MNBH

Tag

GST

Storage

Store at -80°C.

Applications

Research Use

Grade

Crystallography grade protein

Size

0.5mg / 1mg

* For Research Use Only.

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