Recombinant Human SMARCA4 Protein (aa 1448-1575) , GST-tagged

Product Details

Catalog

CPB-B004

Product Name

Protein Name

Transcription activator BRG1

UniProt

P51532

Type

BROMODOMAINS PROTEINS

Description

High purity crystallization grade drug target recombinant proteins are ready to be shipped to customers for research purposes. The proteins have been purified to a high degree, characterized and crystallized.

Origin

Human

Source

E. coli

Gene Information

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. BRG1 is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin. BRG1 is mutated in many cancer cell lines, such as breast, prostate, lung, pancreas and colon. Further, BRG1 has an important role as a tumor suppressor. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

Synonyms

BRG1, BAF190A, SNF2B, SNF2L4

Tag

GST

Storage

Store at -80°C.

Applications

Research Use

Grade

Crystallography grade protein

Size

0.5mg / 1mg

* For Research Use Only.

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