Recombinant Human TIM3 Protein (aa 22-200), HIgG1 Fc-tagged

Product Details

Catalog

CPB-B075

Product Name

Protein Name

T-cell immunoglobulin and mucin domain-containing protein 3

UniProt

Q8TDQ0

Type

OTHERS PROTEINS

Description

High purity crystallization grade drug target recombinant proteins are ready to be shipped to customers for research purposes. The proteins have been purified to a high degree, characterized and crystallized.

Origin

Human

Source

CHO cells

Gene Information

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

Synonyms

HAVCR2, TIMD3

Tag

HIgG1 Fc

Storage

Store at -80°C.

Applications

Research Use

Grade

Crystallography grade protein

Size

0.5mg / 1mg

* For Research Use Only.

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